Diphenhydramine - instructions for use, dose, side effects, contraindications

Blocker H₁-gistaminovyh receptors of the first generation. Action on the central nervous system is caused by blockade H₃histamine receptors and brain m-cholinergic receptors. Reduces or prevents spasm caused by histamine smooth muscle, increased capillary permeability, swelling of the tissues, itching and flushing, has a local anesthetic (with ingestion), antiemetic, sedative effects, has a hypnotic effect.

Antagonism with histamine manifests itself in a greater degree in relation to local vascular reactions in inflammation and allergies than in systemic, ie. lowering blood pressure. However, with parenteral administration, patients with circulating blood volume deficiency may reduce blood pressure and increase the available arterial hypotension.In people with local brain damage and epilepsy activates (even in low doses) epileptic discharges on the electroencephalogram and can provoke an epileptic attack.

The action develops within a few minutes, the duration is up to 12 hours.

Pharmacokinetics:The connection with plasma proteins is 98 - 99%. It penetrates the blood-brain barrier, it is metabolized mainly in the liver, in part - in the lungs and kidneys. It is excreted from the tissues after 6 hours. The half-life period is 4-10 hours. Within a day it is completely excreted by the kidneys in the form of metabolites conjugated with glucuronic acid. Essential amounts are excreted in milk and can cause sedation in infants (a paradoxical reaction characterized by excessive excitability may be observed).

Indications:In complex therapy - anaphylactic and anaphylactoid reactions, Quincke's edema, serum sickness.

Contraindications:Hypersensitivity, bronchial asthma, zakratougolnaya glaucoma, prostatic hyperplasia, stenosing peptic ulcer of the stomach and duodenum, stenosis of the neck of the bladder, epilepsy, lactation, children under 7 months.

Carefully:Pregnancy.

Pregnancy and lactation:The use of the drug during pregnancy is possible only if the intended benefit to the mother exceeds the potential risk to the fetus. For the duration of treatment, stop lactation.

Dosing and Administration:

Intravenous or intramuscular.

For adults and children over 14 years of age, intravenously or intramuscularly, 1-5 ml of a 1% solution (10-50 mg) 1-3 times a day; the maximum daily dose is 200 mg. For children aged 7 to 12 months, 0.3-0.5 ml (3-5 mg), 1 to 3 years, 0.5-1 ml (5-10 mg), 4 to 6 years for 1-1.5 ml (10-15 mg), from 7 to 14 years for 1.5-3 ml (15-30 mg), if necessary, every 6-8 hours.

Side effects:

Allergic reactions:

urticaria, photosensitivity, skin rash and itching, anaphylactic shock.

From the nervous system:

drowsiness, weakness, decreased speed of psychomotor reaction, impaired coordination of movements, confusion, headache, dizziness, sedation, tremor, irritability, anxiety, nervousness, euphoria, agitation (especially in children), insomnia, paresthesia, neuritis, convulsions.

From the digestive system:

nausea, vomiting, discomfort in the epigastric region, anorexia, dryness of the oral mucosa, epigastric pain, diarrhea, constipation.

From the respiratory system:

dryness of the mucous membrane of the nasal cavity, bronchi (increased viscosity of sputum), a feeling of squeezing in the chest or throat, sneezing, nasal congestion.

From the hematopoiesis:

hemolytic anemia, thrombocytopenia, agranulocytosis.

From the cardiovascular system:

lowering of arterial pressure, tachycardia, extrasystole, palpitation.

From the genitourinary system:

rapid or difficult urination, urinary retention, early menstruation.

From the sense organs:

impaired visual perception, diplopia, vertigo, tinnitus, acute labyrinthitis.

Other:

increased sweating, chills.

Overdose:

Symptoms: depression or excitation (especially in children) of the central nervous system, including depression, dilated pupils, dry mouth, upset of the functions of the gastrointestinal tract.

Treatment: there is no specific antidote. Supportive measures include monitoring blood pressure, drugs that increase blood pressure, oxygen, introduction of plasma-substituting fluids intravenously.

Can not use epinephrine and analeptics.

Interaction:

Strengthens the action of ethanol and drugs that depress the central nervous system.

Monoamine oxidase inhibitors increase the anticholinergic activity of diphenhydramine. Antagonistic interaction is noted when combined with psychostimulants.

Reduces the effectiveness of apomorphine as an emetic drug in the treatment of poisoning.

Enhances the anticholinergic effects of drugs with m-cholinoblocking activity.

Special instructions:

Do not administer subcutaneously due to irritant effect.

During treatment with diphenhydramine, you should avoid ultraviolet radiation and refrain from using ethanol.

It is necessary to inform the doctor about the use of this drug: an antiemetic effect may make it difficult to diagnose appendicitis and to recognize the symptoms of an overdose by other means.

Effect on the ability to drive transp. cf. and fur:

During drug treatment caution should be exercised when controlling vehicles, mechanisms, and also when engaging in other potentially hazardous activities requiring increased concentration of attention and speed of psychomotor reactions.

Form release / dosage:

Solution for intravenous and intramuscular injection 10 mg / ml.

Packaging:

1 ml per ampoule of neutral glass.

10 ampoules are placed in a box of cardboard. In each box, the instructions for use and the ampoule scaler are put.

5 ampoules are placed in a contour mesh package made of PVC film. 2 contour mesh packages together with the instruction for use and the ampoule scarifier are put in a pack of cardboard. When packing ampoules with a dot or a ring of fracture, the scarifier is not inserted.

Storage conditions:

In the dark place at a temperature of 2 to 30 ° C.

Keep out of the reach of children.

Shelf life:

5 years.

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LS-000785

Date of registration:23.07.2010 / 02.04.2012

The owner of the registration certificate:MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC Russia

Manufacturer: & nbsp

MOSHIMFARM PREPARATES them. NA Semashko OJSC Russia

Information update date: & nbsp02.02.2016

Illustrated instructions

Instructions

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