Active substanceDiphenhydramineDiphenhydramine
Similar drugsTo uncover
  • Dimedrol
    solution w / m in / in 
    BELMEDPREPARATY, RUP     Republic of Belarus
  • Dimedrol
    pills inwards 
    BELMEDPREPARATY, RUP     Republic of Belarus
  • Dimedrol
    solution w / m in / in 
  • Dimedrol
    solution w / m in / in 
       
  • Dimedrol
    solution w / m in / in 
    DALHIMFARM, OJSC     Russia
  • Dimedrol
    pills inwards 
    DALHIMFARM, OJSC     Russia
  • Dimedrol
    pills inwards 
    BIOSINTEZ, PAO     Russia
  • Dimedrol
    solution w / m in / in 
    FARMENT FIRM, LLC     Russia
  • Dimedrol
    solution w / m in / in 
    ATOLL, LLC     Russia
  • Dimedrol
    pills inwards 
  • Dimedrol
    solution w / m 
  • Dimedrol
    solution w / m in / in 
    SAMSON-MED, LLC     Russia
  • Dimedrol
    solution w / m in / in 
    BIOSINTEZ, PAO     Russia
  • Dimedrol
    solution w / m in / in 
    VELFARM, LLC     Republic of San Marino
  • Dimedrol Avecsima
    pills inwards 
  • Dimedrol Beefus
    solution w / m in / in 
    UPDATE OF PFC, CJSC     Russia
  • Dimedrol-Vial
    solution w / m in / in 
    VIAL, LLC     Russia
  • Dimedrol-UBF
    pills inwards 
    URALBIOFARM, OJSC     Russia
  • Psylo-balsam®
    gel externally 
  • Dosage form: & nbspSolution for intravenous and intramuscular injection
    Composition:
    Active substance:
    Diphenhydramine hydrochloride (dimedrol) - 10 mg
    Auxiliary substance;
    Water for injection - up to 1 ml
    Description:Transparent colorless liquid.
    Pharmacotherapeutic group:Antiallergic agent (H1-histamine receptor blocker)
    ATX: & nbsp

    A.06.A.A.02   Diphenhydramine

    Pharmacodynamics:
    The H1 blocker is the first-generation histamine receptor. The effect on the central nervous system is due to the blockade of H1-histamine receptors and m-cholinoreceptors of the brain. Reduces or prevents histamine-induced spasms of smooth muscles, increased capillary permeability, tissue swelling, pruritus and hyperemia, has a local anesthetic, antiemetic, sedative effects, has a hypnotic effect. Antagonism with histamine manifests itself more in relation to local vascular reactions in inflammation and allergies than to systemic ones, that is, lowering blood pressure. However, with parenteral administration, patients with circulating blood volume deficiency may reduce blood pressure and increase the existing hypotension.In people with local brain damage and epilepsy activates (even in low doses) epileptic discharges on the electroencephalogram and can provoke an epileptic attack.
    The action develops within a few minutes, the duration is up to 12 hours.
    Pharmacokinetics:After intravenous and intramuscular administration, diphenhydramine is widely distributed in the body, the maximum concentration is achieved in 20-40 minutes. It passes well through the blood-brain barrier and the placenta. More than 99% binds to plasma proteins. Metabolised in the liver. Half-life is 1-4 hours. Excreted in milk and may cause sedation in infants breastfed. Within a day is completely excreted from the body mainly in the form of benzhydrol conjugated with glucuronic acid, and only in a small amount - in unchanged form.
    Indications:
    In complex therapy - anaphylactic and anaphylactoid reactions, Quincke's edema, serum sickness.
    Peptic ulcer of stomach and duodenum, hyperacid gastritis (as part of combination therapy).
    Parkinsonism, chorea, insomnia.
    Vomiting of pregnant women, Meniere's syndrome, sea and air sickness, radiation sickness. Extensive traumatic damage to the skin and soft tissues (burns, crushing), hemorrhagic vasculitis, serum sickness.
    Premedication.
    Contraindications:Hypersensitivity, zakratougolnaya glaucoma, prostatic hyperplasia, stenosing peptic ulcer of the stomach and duodenum, stenosis of the neck of the bladder, bronchial asthma, epilepsy, children under 7 months.
    Carefully:Pregnancy, lactation.
    Pregnancy and lactation:Carefully.
    Dosing and Administration:
    Method of administration: intravenously or intramuscularly.
    For adults and children over 14 years of age, intravenously or intramuscularly, 1 to 5 ml of a solution of 10 mg / ml (10-50 mg) 1-3 times a day; the maximum daily dose is 200 mg.
    For children aged 7 months to 12 months, 0.3-0.5 ml (3 - 5 mg), 1 to 3 years 0.5-1 ml (5-10 mg), 4 to 6 years 1 to 1.5 ml (10 to 15 mg), from 7 to 14 years, 1.5 to 3 ml (15 to 30 mg), if necessary, every 6 to 8 hours.
    Side effects:
    Allergic reactions:
    urticaria, photosensitivity, skin rash, itching, anaphylactic shock.
    From the nervous system:
    drowsiness, nervousness, insomnia, euphoria, general weakness, fatigue, sedation, loss of attention, headache, impaired coordination, anxiety, increased excitability (especially in children), irritability, confusion, consciousness, tremor, neuritis, convulsions, paresthesia, impaired vision, diplopia, acute labyrinthitis, tinnitus, can provoke an epileptiform attack.
    From the digestive system:
    dry mouth, short-term numbness of the oral mucosa, anorexia, diarrhea, constipation, nausea, epigastric distress, vomiting.
    From the respiratory system:
    dryness of the mucous membrane of the mouth, nose, bronchi (increased viscosity of sputum), tightness in the chest.
    From the hematopoiesis:
    hemolytic anemia, thrombocytopenia, agranulocytosis.
    From the side of the cardiovascular system and blood:
    hypotension, palpitation, tachycardia, extrasystole, agranulocytosis, thrombocytopenia, hemolytic anemia.
    From the urinary system:
    disturbances of urination.
    Other:
    sweating, chills, photosensitivity.
    Overdose:
    Symptoms: depression of the central nervous system, development of excitation (especially in children) or depression, dilated pupils, dry mouth, paresis of the organs of the gastrointestinal tract.
    Treatment: there is no specific antidote, gastric lavage, if necessary - drugs that increase blood pressure, oxygen, intravenous injection of plasma-substituting fluids. Can not use epinephrine and analeptics.
    Interaction:
    Strengthens the action of ethanol and drugs that depress the central nervous system.
    Monoamine oxidase inhibitors increase the anticholinergic activity of diphenhydramine.
    Antagonistic interaction is noted when co-administered with psychostimulants.
    Reduces the effectiveness of apomorphine as an emetic drug in the treatment of poisoning.
    It enhances the anticholinergic effects of the drug with m-cholinoblocking activity.
    Special instructions:
    During treatment with diphenhydramine, you should avoid ultraviolet radiation and use of ethanol.
    It is necessary to inform the doctor about the use of this drug: antiemetic action may make it difficult to diagnose appendicitis and recognizesymptoms of overdose with other medicines.
    The drug dosage form does not provide for its use for subcutaneous administration.
    Effect on the ability to drive transp. cf. and fur:During the period of treatment, it is not allowed to drive vehicles and engage in other potentially hazardous activities requiring an increased concentration of attention and speed of psychomotor reactions.
    Form release / dosage:Solution for intravenous and intramuscular injection 10 mg / ml. in ampoules of 1 ml.
    Packaging:For 10 ampoules together with instructions for use and a knife for opening ampoules or a scarifier ampoule in a box of cardboard.
    5 ampoules per contour cell pack.
    2 contoured cell packs together with instructions for use and a knife for opening ampoules or a scarifier ampullum in a pack of cardboard.
    When using ampoules with notches, rings and dots for opening ampoules and scarifiers do not invest.
    Storage conditions:
    In the dark place at a temperature of 2 to 25 ° C.
    Keep out of the reach of children.
    Shelf life:5 years. Do not use after the date shown on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:P N003993 / 01
    Date of registration:27.01.2010 / 10.08.2011
    The owner of the registration certificate:DALHIMFARM, OJSC DALHIMFARM, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp04.02.16
    Illustrated instructions
      Instructions
      Up