Active substanceHydrocortisoneHydrocortisone
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  • Dosage form: & nbspointment for external use
    Composition:

    Active substance: hydrocortisone acetate - 1.00 g.

    Excipients: Vaseline - 45.00 g; lanolin - 10,00 g; pentaerythritol dioleate 5.00 g; stearic acid - 3.00 g; methyl parahydroxybenzoate 0.08 g; propyl parahydroxybenzoate 0.02 g; water - up to 100.00 g.

    Description:Ointment from white with a yellowish tinge to a light yellow color, with a characteristic odor.
    Pharmacotherapeutic group:Glucocorticosteroid for topical application
    ATX: & nbsp

    S.01.B.A.02   Hydrocortisone

    H.02.A.B.09   Hydrocortisone

    D.07.A.A.02   Hydrocortisone

    Pharmacodynamics:

    Hydrocortisone is a synthetic glucocorticosteroid drug for external use. Has anti-inflammatory, anti-edematous, antipruritic effect. It inhibits the release of cytokines (interleukins and interferon) from lymphocytes and macrophages, inhibits the release of eosinophils mediators of inflammation, disrupts the metabolism of arachidonic acid and the synthesis of prostaglandins. Reduces inflammatory cell infiltrates, reduces the migration of leukocytes, incl.lymphocytes into the area of ​​inflammation.

    Pharmacokinetics:

    Suction

    After application, the active substance accumulates in the epidermis, mainly in the granular layer, systemic absorption is negligible. A small amount of hydrocortisone is absorbed into the systemic blood stream unchanged.

    Metabolism

    Most of hydrocortisone is metabolized directly in the epidermis, and later in the liver.

    Excretion

    Metabolites and a small part of unchanged hydrocortisone is excreted by the kidneys and through the intestine.

    Indications:

    Superficial, uninfected, sensitive to local glucocorticosteroids skin diseases:

    - dermatitis, including atopic, contact, seborrhoeic;

    - eczema;

    - psoriasis.

    If necessary, please consult with your doctor before using the medication.

    Contraindications:

    Hypersensitivity to hydrocortisone and any of the excipients of the drug; wound, ulcerative skin lesions, bacterial, viral and fungal skin infections; tuberculosis, syphilis; rosacea, vulgar acne, perioral dermatitis; skin tumors, post-vaccination reactions, children under 2 years old.

    Carefully:

    Diabetes mellitus, tuberculosis (systemic damage), application to the skin and intertriginoznuyu skin, the use of occlusive dressings, applying to large areas of the skin, and / or long-term treatment (especially in children), pregnancy (application to large areas of skin, long-term treatment) lactation period (use in large doses and / and for a long time).

    Pregnancy and lactation:

    Pregnancy

    The safety of hydrocortisone during pregnancy and during breastfeeding has not been studied. Glucocorticosteroids penetrate the placental barrier. Long-term treatment and use of large doses during pregnancy should be avoided due to the threat of adverse effects on fetal development.

    Breastfeeding period

    Glucocorticosteroids are excreted in breast milk. In the case where the use of glucocorticosteroid in large doses and / or for a long time, it is necessary to stop breastfeeding.

    Dosing and Administration:

    Outwardly. The drug is preferably used in acute and subacute skin processes (without wetting).

    The drug is applied to the affected areas of the skin with a thin layer 1-3 times a day. To improve penetration, the drug is applied with light massaging movements. When there is a positive dynamics, the frequency of application of the drug can be reduced to 2-3 times a week. The course of treatment is 1-3 weeks. In children, the course of treatment should not exceed 7 days.

    If there is no improvement after treatment or new symptoms appear, it is necessary to consult a doctor. Use the drug only according to the method of administration and the doses specified in the instructions. If necessary, please consult with your doctor before using the medication.

    Side effects:

    Hyperemia, puffiness, itching and irritation of the skin in places of ointment application.

    With prolonged use of a glucocorticosteroid, it is possible to develop secondary infectious skin lesions, atrophic changes, hypertrichosis.

    When applied to large surfaces and / or the use of occlusion, it is possible to develop symptoms of hypercorticism (hyperglycemia, glucosuria, reversible suppression of adrenal cortex function, manifestation of Isenko-Cushing syndrome) as a manifestation of the resorptive action of hydrocortisone.

    If any of the side effects indicated in the manual are aggravated, or any other side effects not indicated in the instructions are noted, you should inform the doctor immediately.

    Overdose:

    Acute overdose is unlikely, however, when using the drug on large areas of affected skin with increased resorption capacity, for a long time or with the use of an occlusive dressing, a chronic overdose is possible, accompanied by signs of hypercorticoidism.

    Treatment: symptomatic, if necessary, correction of water-electrolyte balance, cancellation of the drug (with prolonged therapy - gradual cancellation).

    Interaction:

    Hydrocortisone interactions with external use with other drugs have not been identified.

    Special instructions:

    If signs of hypersensitivity or skin irritation associated with the use of the drug are noted, discontinue treatment and consult a doctor. With prolonged treatment, when applying the drug on the vast surface of the skin, with the use of occlusive dressings,and also in children the systemic absorption of a glucocorticosteroid is possible; it is possible to suppress the function of the hypothalamic-pituitary-adrenal system and the development of symptoms of hypercorticism.

    On the skin of the face more often than on other surfaces of the body, after prolonged treatment with local glucocorticosteroids, atrophic changes may appear; the course of treatment in this case should not exceed 5 days.

    Care should be taken when applying the product to the face, wrinkles, the area of ​​natural folds, to areas with thin skin.

    Avoid contact with eyes. Do not apply the drug to mucous membranes. It should be borne in mind that glucocorticosteroids are capable of altering the manifestations of certain skin diseases, which can make diagnosis more difficult. In addition, the use of glucocorticosteroids may be the cause of delayed wound healing.

    With prolonged therapy with glucocorticosteroids, sudden discontinuation of therapy can lead to the development of a bounce syndrome that manifests itself in the form of dermatitis with intense redness of the skin and a burning sensation. Therefore, after long-term treatment, the drug should be abolished gradually, for example, by switching to an intermittent treatment regimen before it is completely discontinued.Propyl parahydroxybenzoate, which is part of the drug, can cause allergic reactions (possibly delayed type). In such cases, the drug should be discontinued.

    Pediatric Use

    The drug can be used in children from 2 years. It should be borne in mind that in young children, skin folds, diapers, diapers can have an effect similar to the effect of an occlusive dressing, and increase systemic resorption glucocorticosteroid. In addition, children can have a greater degree of systemic resorption due to the relationship between skin surface and body weight, and also due to insufficient maturation of the skin. Long-term treatment of children with a glucocorticosteroid can lead to disruption of their growth and development. Therefore, long-term use of the drug should be carried out under the supervision of a doctor. Children should receive a minimum dose of the drug sufficient to achieve the effect. In children, the course of treatment should not exceed 7 days.

    Effect on the ability to drive transp. cf. and fur:

    The drug does not affect the ability to drive vehicles and perform other potentially hazardous activities.

    Form release / dosage:

    Ointment for external use 1%.

    Packaging:

    By 10, 30 grams into tubes are aluminum.

    One tube with the instruction for use is placed in a cardboard package (bundle).

    Storage conditions:

    Store at a temperature not exceeding 25 ° C. Keep out of the reach of children.

    Shelf life:

    3 years. Do not use the drug after the expiration date.

    Terms of leave from pharmacies:Without recipe
    Registration number:LP-004540
    Date of registration:14.11.2017
    Expiration Date:14.11.2022
    The owner of the registration certificate:ATOLL, LLC ATOLL, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp07.12.2017
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