Hydrocortisone - instructions for use, dose, side effects, contraindications

Pharmacodynamics:Hydrocortisone is a natural glucocorticosteroid. Has anti-inflammatory, anti-allergic effect. Reduces inflammatory cell infiltrates, reduces the migration of leukocytes and lymphocytes to the area of inflammation. Stabilizes cellular and subcellular, including lysosomal membranes and membranes of mast cells. Reduces the binding of immunoglobulins to receptors on the cell surface and inhibits the synthesis or release of cytokines (interleukins and interferon) from lymphocytes and macrophages.Reduces the release of arachidonic acid from phospholipids and the synthesis of its metabolites (prostaglandins, leukotrienes, thromboxane). Reduces the exudative reaction, helps reduce the permeability of capillaries. Reduces severity of early immunological response. Has catabolic action and inhibits the development of connective tissue and scarring.

Pharmacokinetics:Hydrocortisone poorly penetrates the cornea into the intraocular fluid.

Hydrocortisone penetrates the epidermis and epithelium of the mucous membrane, can be slightly absorbed into the systemic circulation and exert systemic action. Hydrocortisone is metabolized directly in the epidermis and epithelium of the mucous membrane, in the future a small amount of it after absorption enters the total blood flow and biotransforms in the liver. In blood, 80% is associated with transcortin and 10% with albumin. Metabolites hydrocortisone is derived through the kidneys and intestines.

Indications:

- allergic eye diseases (dermatitis of the eyelids, blepharitis, conjunctivitis and keratoconjunctivitis);

- inflammatory diseases of the eyes of the anterior part of the eye in the absence of violation of the integrity of the corneal epithelium; (blepharitis, conjunctivitis and keratoconjunctivitis);

- thermal and chemical burn (after complete epithelialization of corneal defects).

Contraindications:

- hypersensitivity to the components of the drug;

- purulent, viral, tuberculosis, fungal diseases of the eyes;

- glaucoma;

- trachoma;

- the period of vaccination;

- violation of the integrity of the shells of the eye;

- age to 18 years.

Carefully:Not described.

Pregnancy and lactation:

Studies of the safety and efficacy of hydrocortisone in pregnant and lactating women have not been conducted. There is no accurate data on the penetration of breast glucocorticosteroids in topical application. However, the risk can not be ruled out completely. The use of hydrocortisone in pregnant and lactating women is allowed only by appointment by the attending physician, when the expected therapeutic effect for the mother exceeds the potential risk to the fetus and the baby.

Duration of application should not exceed 7-10 days.

Dosing and Administration:

Locally.

In the conjunctival sac, 1 cm of eye ointment is administered 2-3 times a day.

The course of treatment is 1-2 weeks. On the recommendation of a doctor, a course of treatment can be extended.

Side effects:Allergic reactions, burning, injected sclera, short-term blurring of vision.

With prolonged use for more than 10 days, the following can be observed:

- increased intraocular pressure with possible subsequent development of steroid glaucoma with optic nerve damage and violation of the visual fields (therefore, when using preparations containing glucocorticosteroids for more than 10 days, intraocular pressure should be measured regularly);

- formation of posterior subcapsular cataract;

- slowing down the process of wound healing (with diseases that cause thinning of the cornea, its perforation is possible).

Secondary bacterial infection may occur as a consequence of suppression of the protective reaction of the patient's body. In acute purulent diseases of the eye, glucocorticosteroids can mask or strengthen the existing infectious process.

Fungal infection of the cornea tends to occur especially, often with prolonged use of glucocorticosteroids. The appearance of non-healing ulcers on the cornea after prolonged treatment with glucocorticosteroids may indicate the development of fungal infestation.

Overdose:Overdose is extremely rare. Symptoms of overdose: there may be local dose-dependent side effects. When the drug is canceled, the overdose phenomena pass by themselves.

Interaction:

With prolonged use of the drug with possible resorption of the drug into the total bloodstream, hydrocortisone reduces the effectiveness of insulin, oral hypoglycemic drugs, antihypertensive drugs, anticoagulants, reduces the concentration of salicylates in the blood, reduces the concentration of praziquantel in the blood serum. Increase the risk of side effects of hydrocortisone: androgens, estrogens, oral contraceptives, anabolic steroids (hirsutism, acne); antipsychotic drugs, carbutamide, azathioprine (cataract); holinoblokatory, antihistamine medicines, tricyclic antidepressants, nitrates (glaucoma); diuretics (hypokalemia).

When used with cardiac glycosides, it is possible to develop digitalis intoxication. Simultaneous use of lead and silver leads to mutual inactivation.

Special instructions:

During the treatment, contact lenses are not recommended. When using eye drops, the time interval between their instillation and application of the ointment is at least 15 minutes.

If you use more than 10 days and have a history of open or closed angle glaucoma, you need to monitor the intraocular pressure.

Shelf life after opening a tube - 1 month.

Effect on the ability to drive transp. cf. and fur:If the patient after the application of the drug temporarily reduces the clearness of vision, until it is restored, it is not recommended to drive and engage in activities that require clarity of visual perception.

Form release / dosage:

Ointment eye 0.5%.

Packaging:By 3.0 g and 5.0 g in aluminum tubes. Each tube with instruction for use is placed in a cardboard pack.

Storage conditions:At a temperature of 5 to 15 ° C. Keep out of the reach of children.

Shelf life:2 years. Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LS-002379

Date of registration:14.02.2011

Expiration Date:Unlimited

The owner of the registration certificate:SYNTHESIS, OJSC SYNTHESIS, OJSC Russia

Manufacturer: & nbsp

SYNTHESIS, OJSC Russia

Information update date: & nbsp04.04.2017

Illustrated instructions

Instructions

Hydrocortisone (Hydrocortisone)