Hydrocortisone - instructions for use, dose, side effects, contraindications

Glucocorticosteroid, has anti-inflammatory and anti-allergic effect. Reduces inflammatory cell infiltrates, reduces the migration of leukocytes and lymphocytes to the area of inflammation. One hundredbiliziruet cellular and subcellular, including lysosomal membranes and membranes of mast cells. Reduces the binding of immunoglobulins to receptors on the cell surface and inhibits the synthesis or release of cytokines (interleukins and interferon) from lymphocytes and macrophages.Reduces the exudative reaction, contributes to a decrease in the permeability of capillaries. Reduces the severity of early immunological response. It has an antimetabolic effect and inhibits the development of connective tissue and scarring.

Pharmacokinetics:

Hydrocortisone poorly penetrates the cornea into the intraocular fluid; penetrates the epidermis and epithelium of the mucosa, can be slightly absorbed into the systemic circulation and exert systemic action. Metabolized directly in the epidermis and epithelium of the mucous membrane, and later a small amount of it after absorption enters the total blood flow and is metabolized in the liver. In blood, 80% is associated with transcortin and 10% with albumin. Metabolites of hydrocortisone are excreted by the kidneys and intestines.

Indications:

Allergic eye diseases (dermatitis of the eyelids, blepharitis, conjunctivitis and keratoconjunctivitis).

Inflammatory diseases of the anterior part of the eye in the absence of violation of the integrity of the epithelium of the cornea (blepharitis, conjunctivitis and keratoconjunctivitis).

Thermal and chemical eye burn (after complete epithelialization of corneal defects).

Contraindications:

Hypersensitivity, purulent, viral, tuberculosis, fungal diseases of the eyes, glaucoma, trachoma, the period of vaccination, violation of the integrity of the membranes of the eye, children's age (under 18 years).

Carefully:

Pregnancy, lactation.

Pregnancy and lactation:

Studies of the safety and efficacy of hydrocortisone during pregnancy and lactation were not conducted.

There are no precise data on the penetration of glucocorticosteroids into breast milk in topical application, but the risk can not be completely ruled out. The use of hydrocortisone during pregnancy and lactation is possible only when the expected therapeutic effect exceeds the potential risk to the fetus or child. The duration of application in these cases should not exceed 7-10 days.

Dosing and Administration:

Locally. A strip of ointment 1-2 cm is placed behind the lower eyelid 2-3 times a day. The course of treatment - 1-2 weeks. On the appointment of a doctor, the course of treatment can be extended.

Side effects:

Allergic reactions, burning, injected sclera, short-term blurred vision.

With prolonged use for more than 10 days, there may be: increased intraocular(with the use of glucocorticosteroids for more than 10 days, the intraocular pressure should be regularly measured), the formation of posterior subcapsular cataracts, the slowing down of the wound healing process (with diseases that cause thinning of the cornea, it is possible to perforate it), with the possible subsequent development of steroid glaucoma with optic nerve damage and visual field disturbance ).

Secondary bacterial infection can occur as a consequence of suppression of the body's defense reaction. In acute purulent diseases, glucocorticosteroids can mask or enhance the existing infectious process.

Fungal infection of the cornea tends to occur especially often with prolonged use of glucocorticosteroids. The appearance of non-healing ulcers on the cornea after prolonged treatment with glucocorticosteroids may indicate the development of fungal infestation.

Overdose:

Overdose is extremely rare.

Symptoms: There may be local side effects.

When the drug is canceled, the overdose phenomena pass by themselves.

Interaction:

With prolonged use of the drug due to possible resorption into the systemic circulation, hydrocortisone can reduce the effectiveness of insulin, oral hypoglycemic, antihypertensive drugs, anticoagulants, the concentration of salicylates and praziquantel in blood plasma.

The risk of side effects of hydrocortisone is increased: androgens, estrogens, oral contraceptives, anabolic steroids (hirsutism, acne); antipsychotic drugs, carbutamide, azathioprine (cataract); holinoblokatory, antihistamine medicines, tricyclic antidepressants, nitrates (glaucoma); diuretics (hypokalemia).

When used with cardiac glycosides, it is possible to develop digitalis intoxication.

Simultaneous use of lead and silver leads to mutual inactivation.

Special instructions:

During the treatment, contact lenses are not recommended. With the simultaneous use of eye drops, the time interval between their instillation and application of the ointment should be at least 15 minutes.

If you use more than 10 days and have a history of open or closed angle glaucoma, you need to monitor the intraocular pressure.

Effect on the ability to drive transp. cf. and fur:If the patient after application of the drug temporarily reduces the clearness of vision, until it is restored, it is not recommended to drive vehicles and engage in activities that require clarity of visual perception.

Form release / dosage:

Eye Ointment 0,5 %.

Packaging:By 3 g and 5 g in aluminumwould. Each tube together with the instructionsfor her use in a pack.

Storage conditions:

At a temperature of 5 to 20 ° C. Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LS-002358

Date of registration:01.04.2011 / 11.09.2012

Expiration Date:Unlimited

The owner of the registration certificate:TATHIMFARMPREPARATY, JSC TATHIMFARMPREPARATY, JSC Russia

Manufacturer: & nbsp

TATHIMFARMPREPARATY, JSC Russia

Information update date: & nbsp04.04.2017

Illustrated instructions

Instructions

Hydrocortisone (Hydrocortisone)