Hydrocortisone - instructions for use, dose, side effects, contraindications

Glucocorticosteroid. Has anti-inflammatory and anti-allergic effect. Reduces inflammatory cell infiltrates, reduces the migration of leukocytes and lymphocytes to the area of inflammation. Stabilizes cellular and subcellular, incl. lysosomal membranes and membranes of mast cells. Reduces the binding of immunoglobulins to receptors on the cell surface and inhibits the synthesis or release of cytokines (interleukins and interferon) from lymphocytes and macrophages.Reduces the exudative reaction, contributes to a decrease in the permeability of capillaries. Reduces the severity of early immunological response. It has an antimetabolic effect and inhibits the development of connective tissue and scarring.

Pharmacokinetics:

Hydrocortisone poorly penetrates the cornea into the intraocular fluid. Hydrocortisone penetrates the epidermis and epithelium of the mucosa, can be slightly absorbed into the systemic circulation and exert systemic action. Metabolized directly in the epidermis and epithelium of the mucous membrane, and later a small amount of it after absorption enters the total blood flow and is metabolized in the liver. In blood, 80% is associated with transcortin and 10% with albumin. Metabolites of hydrocortisone are excreted by the kidneys and intestines.

Indications:

Allergic eye diseases (dermatitis of the eyelids, blepharitis, conjunctivitis and keratoconjunctivitis).

Inflammatory diseases of the anterior part of the eye in the absence of violation of the integrity of the epithelium of the cornea (blepharitis, conjunctivitis and keratoconjunctivitis).

Thermal and chemical eye burn (after complete epithelialization of corneal defects).

Contraindications:

Hypersensitivity, purulent, viral, tuberculosis, fungal diseases of the eyes, glaucoma, trachoma, the period of vaccination, violation of the integrity of the membranes of the eye, children's age (under 18 years).

Carefully:not described

Pregnancy and lactation:

Studies of the safety and efficacy of hydrocortisone in pregnant and lactating women have not been conducted. There is no accurate data on the penetration of breast corticosteroids in topical application. However, the risk can not be ruled out completely. The use of hydrocortisone in pregnant and lactating women is allowed only by appointment by the attending physician, when the expected curative effect exceeds the potential risk to the fetus or the child.

Duration of application should not exceed 7-10 days.

Dosing and Administration:

Locally. In the conjunctival sac, 1 cm of eye ointment is administered 2-3 times a day. The course of treatment is 1-2 weeks. On the recommendation of a doctor, a course of treatment can be extended.

Side effects:

Allergic reactions, burning, injected sclera, short-term blurred vision.

With prolonged use for more than 10 days, there may be: increased intraocular pressure withpossible subsequent development of steroid glaucoma with optic nerve damage and violation of the visual fields (therefore, the use of glucocorticosteroid for more than 10 days should regularly measure intraocular pressure), the formation of posterior subcapsular cataract, slowing down the wound healing process (with diseases that cause thinning of the cornea, its perforation is possible).

Secondary bacterial infection can occur as a consequence of suppression of the body's defense reaction. In acute purulent diseases of the eye, glucocorticosteroids can mask or strengthen the existing infectious process.

Fungal infection of the cornea tends to occur especially often with prolonged use of a glucocorticosteroid. The appearance of non-healing ulcers on the cornea after prolonged treatment with a glucocorticosteroid may indicate the development of fungal infestation.

If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, inform the doctor about it.

Overdose:

Overdose is extremely rare.

Symptoms: There may be local side effects.

When the drug is canceled, the overdose phenomena pass by themselves.

Interaction:

With prolonged use of the drug due to possible resorption into the systemic circulation, hydrocortisone can reduce the effectiveness of insulin, oral hypoglycemic, antihypertensive drugs, anticoagulants, the concentration of salicylates and

praziquantel in blood plasma. The risk of side effects of hydrocortisone is increased: androgens, estrogens, oral contraceptives, anabolic steroids (hirsutism, acne); antipsychotic drugs, carbutamide, azathioprine (cataract); cholinergic blockers, antihistamines, tricyclic antidepressants, nitrates (glaucoma); diuretics (hypokalemia).

When used with cardiac glycosides, it is possible to develop digitalis intoxication. Simultaneous use of lead and silver leads to mutual inactivation.

Special instructions:

During the treatment, contact lenses are not recommended. With the simultaneous use of eye drops, the time interval between their instillation and application of the ointment should be at least 15 minutes.

If you use more than 10 days and have a history of open or closed angle glaucoma, you need to monitor the intraocular pressure.

Effect on the ability to drive transp. cf. and fur:

If the patient after the application of the drug temporarily reduces the clearness of vision, until its recovery is not recommended to drive vehicles and engage in activities that require clarity of visual perception.

Form release / dosage:

Eye ointment 0.5% in aluminum tubes of 3 g and 10 g. Each tube, together with the instruction for medical use, is placed in a pack of cardboard.

Packaging:Pack of cardboard

Storage conditions:

At a temperature not higher than 15 ° С.

Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiry date printed on the package.

Shelf life after opening a tube - 3 months.

Terms of leave from pharmacies:Without recipe

Registration number:LP-000449

Date of registration:01.03.2011 / 01.06.2016

Expiration Date:Unlimited

The owner of the registration certificate:MUROMSKY INSTRUMENT-MAKING PLANT, OJSC MUROMSKY INSTRUMENT-MAKING PLANT, OJSC Russia

Manufacturer: & nbsp

MUROMSKY INSTRUMENT-MAKING PLANT, OJSC Russia

Information update date: & nbsp29.10.2012

Illustrated instructions

Instructions

Hydrocortisone (Hydrocortisone)