With prolonged use of the drug with possible resorption of the drug into the total bloodstream, hydrocortisone reduces the effectiveness insulin, oral hypoglycemic drugs, antihypertensive drugs, anticoagulants, reduces the concentration of salicylates in the blood, reduces the concentration of praziquantel in the blood serum. Increase the risk of side effects of hydrocortisone: androgens, estrogens, oral contraceptives, anabolic steroids (hirsutism, acne); antipsychotic facilities, carbutamide, azathioprine (cataract); holinoblokatory, antihistamines, tricyclic antidepressants, nitrates (glaucoma); diuretics (hypokalemia).
When used with cardiac glycosides, the development of glycoside intoxication is possible.
Simultaneous use of lead and silver leads to mutual inactivation.