The classification of side effects is presented: often - 1-10%; infrequently, 0.1-1%; rarely - 0,01-0,1%; very rarely - less than 0.001%, including individual cases.
From the digestive system: often (especially in elderly patients over 65 years of age who have a history of erosive and ulcerative lesions of the gastrointestinal tract) - gastralgia, diarrhea; infrequently - stomatitis, flatulence, constipation, vomiting, sensation of stomach overflow; rarely - nausea, erosive and ulcerative lesions of the gastrointestinal tract (including with perforation and / or bleeding - abdominal pain, spasm or burning in the epigastric region, melena, vomiting like "coffee grounds", nausea, heartburn, etc. ), cholestatic jaundice, hepatitis, hepatomegaly, acute pancreatitis.
From the urinary system: rarely - acute renal failure, back pain with or without hematuria and / or azotemia, hemolytic uremic syndrome (hemolytic anemia, renal failure, thrombocytopenia, purpura), frequent urination, increased or decreased urine volume, nephritis, edema of renal genesis.
From the sense organs: rarely - Hearing loss, ringing in the ears, visual impairment (including blurred vision).
From the respiratory system: rarely - bronchospasm or dyspnea, rhinitis, laryngeal edema (shortness of breath, difficulty breathing).
From the side of the central nervous system: often - headache, dizziness, drowsiness; rarely - aseptic meningitis (fever, severe headache, cramps, stiffness in the neck muscles and / or back), hyperactivity (mood changes, anxiety), hallucinations, depression, psychosis.
From the cardiovascular system: infrequently - Increased blood pressure; rarely - Pulmonary edema, fainting.
On the part of the organs of hematopoiesis: rarely - anemia, eosinophilia, and leukopenia.
From the side of the hemostasis system: rarely - bleeding from a postoperative wound, epistaxis, rectal bleeding.
From the skin: infrequently - skin rash (including maculopapular rash), purpura; rarely - exfoliative dermatitis (fever, chills or without redness, induration or skin peeling, swelling and / or tenderness of the tonsils), rash, Stevens-Johnson syndrome, Lyell syndrome.
Allergic reactions: rarely - anaphylaxis or anaphylactoid reaction (change in skin color, skin rash, hives, itchy skin, tachypnea and dyspnea, edema of the eyelids, periorbital edema, dyspnea, wheezing, heaviness in the chest, wheezing).
Other: often - edema (face, legs, ankles, fingers, feet, weight gain); less often - increased sweating; rarely swelling of the tongue, fever.