Often - more than 3%. less often - 1-3%, rarely - less than 1%.
From the digestive system: often (especially in elderly patients over 65 years of age who have a history of erosive and ulcerative lesions of the gastrointestinal tract) - gastralgia, diarrhea; less often - stomatitis, flatulence, constipation, vomiting, sensation of stomach overflow; rarely - loss of appetite, nausea, erosive and ulcerative lesions of the gastrointestinal tract (including with perforation and / or bleeding - abdominal pain, spasm or burning in the epigastric region, blood in the feces or melena, vomiting with blood or the type of "coffee dense, "nausea, heartburn and other),Cholestatic jaundice, hepatitis, hepatomegaly, acute pancreatitis.
From the urinary system: rarely - Acute renal failure, back pain, hematuria, azotemia, haemolytic-uremic syndrome (hemolytic anemia, renal failure, thrombocytopenia, purpura), frequent urination; increase or decrease in the volume of urine, nephritis, edema of renal genesis.
From the sense organs: rarely - Hearing loss, ringing in the ears, visual impairment (including blurred vision).
From the respiratory system: rarely - bronchospasm or dyspnoea, rhinitis, pulmonary edema, laryngeal edema (shortness of breath, difficulty breathing).
From the central nervous system: often - headache, dizziness, drowsiness, rarely - Aseptic meningitis (fever, severe headache, convulsions, rigidity of the neck and / or back muscles), hyperactivity (mood changes, anxiety), hallucinations, depression, psychosis, fainting.
From the side of the cardiovascular system: less often - Increased blood pressure.
On the part of the organs of hematopoiesis: rarely anemia, eosinophilia, and leukopenia.
From the side of the hemostasis system: rarely - bleeding from a postoperative wound, epistaxis, rectal bleeding.
From the skin: less often - skin rash (including maculopapular rash), purpura, rarely - exfoliative dermatitis (fever with chills or without, hyperemia, densification or flaking of the skin, swelling and / or tenderness of the tonsils), urticaria, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome).
Allergic reactions: rarely anaphylaxis or anaphylactoid reactions (skin discoloration, skin rash, urticaria, skin itching, tachypnea or dyspnea, edema of the eyelids, periorbital edema, shortness of breath, shortness of breath, heaviness in the chest, wheezing).
Other: often - edema and (face, shins, ankles, fingers, feet, weight gain); less often - increased sweating; rarely swelling of the tongue, fever.