Often - more 3%, less often - 1-3%, rarely - less than 1%.
From the digestive system: often (especially in elderly patients, over 65 years of age, having a history of erosive and ulcerative lesions of the gastrointestinal tract) - gastralgia, diarrhea; less often - stomatitis, flatulence, constipation, vomiting, sensation of stomach overflow; rarely - nausea, erosive and ulcerative lesions of the gastrointestinal tract (including with perforation and / or bleeding - abdominal pain, spasm or burning in the epigastric region, blood in the feces or melena, vomiting with blood or the type of "coffee grounds" , nausea, heartburn, etc.), cholestatic jaundice, hepatitis, hepatomegaly, acute pancreatitis.
From the urinary system: rarely - acute renal insufficiency, low back pain with or without hematuria and / or azotemia, hemolytic-uremic syndrome (hemolytic anemia, renal failure, thrombocytopenia, purpura), frequent urination, increase or decrease in urine volume, nephritis, edema of renal genesis.
From the sense organs: rarely - Hearing loss, ringing in the ears, visual impairment (including blurred vision).
From the respiratory system: rarely - bronchospasm or dyspnoea, rhinitis, pulmonary edema, laryngeal edema (shortness of breath, difficulty breathing).
From the C sideHC: often - headache, dizziness, drowsiness; rarely - aseptic meningitis (fever, severe headache, cramps, stiffness in the neck muscles and / or back), hyperactivity (mood changes, anxiety), hallucinations, depression, psychosis.
From the side of the cardiovascular system: less often - increase blood pressure; rarely - faint.
On the part of the organs of hematopoiesis: rarely anemia, eosinophilia, and leukopenia.
From the side of the hemostasis system: rarely - bleeding from a postoperative wound, epistaxis, rectal bleeding.
From the skin: less often - skin rash (including maculopapular rash), purpura; rarely - exfoliative dermatitis (fever, chills or without redness, induration or skin peeling, swelling and / or tenderness of the tonsils), rash, Stevens-Johnson syndrome, Lyell syndrome.
Local Reactions: less often - burning or pain at the injection site.
Allergic Reagents: rarely - Anaphylaxis or anaphylactoid reactions (discoloration of the skin of the face, itching of the skin, tachypnea or dyspnea, edema of the eyelids, periorbital edema, shortness of breath, shortness of breath, heaviness in the chest, wheezing).
Other: often - swelling (face, shins, ankles, fingers, feet, weight gain); less often - increased sweating; rarely swelling of the tongue, fever.