According to the World Health Organization (WHO), adverse events are classified according to their frequency of development as follows: very frequent (> 10%), frequent (> 1% and <10%), infrequent (> 0.1% and <1%), rare (> 0.01% and <0.1%), very rare (<0.01%), the frequency is unknown (the frequency can not be determined based on available data).
Allergic reactions: infrequent - anaphylaxis or anaphylactoid reactions (skin discoloration, skin rash, urticaria, skin itch, tachypnea or dyspnea, edema of the eyelids, periorbital edema, shortness of breath, shortness of breath, heaviness in the chest).
Local Reactions: frequent - burning or pain at the injection site.
From the central nervous system: very frequent - headache; frequent - dizziness, snotty, increased sweating; infrequent - tremor, unusual dreams, hallucinations, euphoria, extrapyramidal symptoms of vertigo, paresthesia, depression, insomnia, nervousness, pathological thinking, loss of concentration, hyperkinesis,stupor, aseptic meningitis (fever, severe headache, cramps, stiff neck and / or back muscles), psychosis, fainting.
From the skin: frequent - itching, rash (including maculopapular rash); infrequent - urticaria, toxic epidermal necrolysis (Lyell's syndrome), malignant exudative erythema (Stevens-Johnson syndrome), exfoliative dermatitis (fever with chills or without, hyperemia, densification or flaking of the skin, enlargement and / or soreness of the tonsils).
From the urinary system: infrequent - hematuria, proteinuria, urinary retention, oliguria, polyuria, frequent urination, acute renal failure, back pain with or without hematuria and / or azotemia, interstitial nephritis, hyponatremia. hyperkalemia, hemolytic-uremic syndrome (hemolytic anemia, renal failure, thrombocytopenia, purpura).
From the digestive system: very frequent - gastralgia, dyspepsia, nausea; frequent - diarrhea, constipation, flatulence, a feeling of fullness of the stomach, vomiting, stomatitis; infrequent - increased or decreased appetite, anorexia,erosive and ulcerative lesions of the gastrointestinal tract (including with perforation and / or bleeding - abdominal pain, spasm or burning in the epigastric region, blood in the feces or melena, vomiting with blood or the type of "coffee grounds", nausea, heartburn ), cholestatic jaundice, hepatitis, hepatomegaly, acute pancreatitis, polydipsia, dry mouth; frequency unknown - exacerbation of ulcerative colitis or Crohn's disease.
From the hematopoiesis: frequent - purple; infrequent - anemia, eosinophilia. From the respiratory system: infrequent - bronchospasm or dyspnea, pulmonary edema, rhinitis, laryngeal edema (difficulty breathing).
From the sense organs: Infrequent - a violation of taste, visual impairment (including blurred vision), decreased hearing, ringing in the ears.
From the side of the cardiovascular system: frequent - increased blood pressure; infrequent - a feeling of palpitations, pallor of the skin, fainting, hyperemia; frequency unknown - lowering of arterial pressure, heart failure, myocardial infarction, stroke.
From the side of the hemostasis system: infrequent - bleeding from a postoperative wound, epistaxis, rectal bleeding.
Other: frequent - edema; infrequent - weight gain, fever, infections, asthenia, increased sweating, swelling of the tongue; the frequency is unknown - an increase in the concentration of urea and creatinine in the blood plasma.