The incidence of side effects is given in accordance with the classification of the World Health Organization: Often - not less than 10%; often - not less than 1% and less than 10%; infrequently - not less than 0.1% and less than 1%; rarely - not less than 0.01% and less than 0.1%; rarely - less than 0.01%, including isolated cases.
From the digestive system: very often - gastralgia, dyspepsia, nausea; often - diarrhea, constipation, flatulence, a feeling of overflow of the stomach, vomiting, stomatitis; infrequent - an increase or decrease in appetite, anorexia, erosive and ulcerative lesions of the gastrointestinal tract (including with perforation and / or bleeding - abdominal pain, spasm or burning in the epigastric region, blood in the feces or melena, vomiting with blood or the type of "coffee grounds", nausea, heartburn, etc.), cholestatic jaundice, hepatitis, hepatomegaly, acute pancreatitis.
From the urinary system: infrequently, hematuria, proteinuria, urinary retention, oliguria, polyuria, increased urination, acute renal failure, low back pain with or without hematuria and / or azotemia, interstitial nephritis, hyponatremia, hyperkalemia, hemolytic uremic syndrome (hemolytic anemia, kidney failure, thrombocytopenia, purpura).
From the sense organs: infrequently - a violation of taste, impaired vision (including blurred vision), decreased hearing, ringing in the ears.
From the respiratory system: infrequently - bronchospasm or shortness of breath, pulmonary edema, rhinitis, laryngeal edema (difficulty breathing). From the central nervous system: very often - headache; often - dizziness, drowsiness, increased sweating; infrequent tremor, unusual dreams, hallucinations, euphoria, extrapyramidal symptoms, vertigo, paresthesia, depression, insomnia, nervousness, polydipsia, dry mouth, pathological thinking, loss of concentration, hyperkinesia, stupor, aseptic meningitis (fever, severe headache, cramps, rigidity of the neck muscles and / or back), psychosis, fainting.
From the side of the cardiovascular system: often - increased blood pressure; infrequently - palpitation, pallor, syncope, hyperemia.
On the part of the organs of hematopoiesis: often - purpura, infrequently anemia, eosinophilia.
From the side of the hemostasis system: infrequently - bleeding from a postoperative wound, epistaxis, rectal bleeding.
From the side of the skinin: often - itching, rash (including maculopapular rash); infrequent urticaria, toxic epidermal necrolysis (Lyell's syndrome), malignant exudative erythema (Stevens-Johnson syndrome), exfoliative dermatitis (fever with chills or without, hyperemia, thickening or flaky skin, enlarged and / or tenderness of the tonsils).
Local reactions: often - burning or pain at the injection site.
Allergic reactions: infrequently anaphylaxis or anaphylactoid reactions (skin discoloration, skin rash, hives, skin itch, tachypnea or dyspnea, edema of the eyelids, periorbital edema, shortness of breath, shortness of breath, chest pain, wheezing).
Other: often - edema (face, legs, ankles, fingers, feet, weight gain); infrequently - weight gain, fever, infection, asthenia, increased sweating, swelling of the tongue.