Often - more than 3%, less often - 1-3%, rarely - less than 1%.
From the digestive system: often - gastralgia, diarrhea; less often - stomatitis, flatulence, constipation, vomiting, sensation of stomach overflow; rarely - decreased appetite, nausea, erosive and ulcerative lesions of the digestive tract (including with perforation and / or bleeding - abdominal pain, spasm or burning in the epigastric region, blood in the feces or melena, vomiting with blood or the type of "coffee thick, "nausea, heartburn, etc.), cholestatic jaundice, hepatitis, hepatomegaly, acute pancreatitis.
From the urinary system: rarely acute renal failure, back pain, hematuria, azotemia, hemolytic-uremic syndrome (hemolytic anemia, renal failure, thrombocytopenia, purpura), increased frequency of urination, increased or decreased volume urine, nephritis, edema of renal genesis.
From the sense organs: rarely - hearing loss, ringing in the ears, visual impairment (including blurred vision).
From the respiratory system: rarely - bronchospasm or dyspnea, rhinitis, pulmonary edema, laryngeal edema (difficulty breathing).
From the central nervous system (CNS): often - headache, dizziness, drowsiness; rarely - aseptic meningitis (fever, severe headache, seizures, neck and / or neck stiffness), hyperactivity (mood changes, anxiety), hallucinations, depression, psychosis, fainting.
From the side of the cardiovascular system (SSS): less often - an increase in blood pressure (BP).
On the part of the organs of hematopoiesis: rarely - anemia, eosinophilia, leukopenia.
From the side of the hemostasis system: rarely bleeding from a postoperative wound, epistaxis, rectal bleeding.
From the skin: less often - skin rash (including maculopapular rash), purpura, rarely - exfoliative dermatitis (fever with chills or without, hyperemia, densification or flaking of the skin, enlargement and / or soreness of palatine tonsils), urticaria, malignant exudative erythema (Stevens-Johnson syndrome ), toxic epidermal necrolysis (Lyell's syndrome).
Local Reactions: less often - burning or pain at the injection site.
Allergic reactions: rarely - anaphylaxis or anaphylactoid reactions (skin discoloration, skin rash, hives, skin itch, tachypnea, edema of the eyelids, periorbital edema, heaviness in the chest, wheezing).
Other: often - swelling (face, legs, ankles, fingers, feet, weight gain); less often - increased sweating, rarely - swelling of the tongue, fever.