From the digestive system: often - gastralgia, diarrhea; less often - stomatitis, flatulence, constipation, vomiting, sensation of stomach overflow; rare - loss of appetite, nausea, erosive and ulcerative lesions of the gastrointestinal tract (including perforation and / or bleeding - abdominal pain, cramping or burning sensation in the epigastric region, blood in the stool or melena, vomiting blood or type of "coffee grounds", nausea, heartburn, etc.), cholestatic jaundice, hepatitis, hepatomegaly, acute pancreatitis.
From the urinary system: rare - acute renal failure, back pain, hematuria, azotemia, hemolytic uremic syndrome (hemolytic anemia, renal failure, thrombocytopenia, purpura), frequent urination, increase or decrease in urine volume, nephritis, edema of renal genesis.
From the sense organs: rarely - hearing loss, ringing in the ears, impaired vision (including blurred vision).
From the respiratory system: rarely - bronchospasm or dyspnoea, rhinitis, pulmonary edema, laryngeal edema (shortness of breath, difficulty breathing).
From the central nervous system: often - headache, dizziness, drowsiness; rarely - aseptic meningitis (fever, severe headache, cramps, stiffness in the neck muscles and / or back), hyperactivity (mood changes, anxiety), hallucinations, depression, psychosis, fainting.
From the side of the cardiovascular system: less often - increased blood pressure.
On the part of the organs of hematopoiesis: rarely - anemia, eosinophilia, leukopenia.
From the side of the hemostasis system: rarely bleeding from a postoperative wound, epistaxis, rectal bleeding.
From the skin: Less frequently - skin rash (including maculopapular rash), purpura, rarely - exfoliative dermatitis (fever, chills or without hyperemia, sealing or skin peeling, swelling and / or tenderness of the tonsils), urticaria, malignant exudative erythema (Stevens syndrome Johnson), toxic epidermal necrolysis (Lyell's syndrome).
Allergic reactions: rarely anaphylaxis or anaphylactoid reactions (skin color change of the face, skin rash, hives, skin itch, tachypnea or dyspnea, edema of the eyelids, periorbital edema, shortness of breath, shortness of breath, chest pain, wheezing).
Other: often - swelling (face, legs, ankles, fingers, feet, weight gain); less frequent - increased sweating; rarely - swelling of the tongue, fever.