The frequency of side effects is classified according to the incidence of the case: often - (1-10%), sometimes (0.1-1%), rarely (0.01-0.1%), very rarely (less than 0.01% ), including individual messages.
From the digestive system: often (especially in elderly patients, over 65 years of age, having a history of erosive and ulcerative lesions of the gastrointestinal tract) - gastralgia, diarrhea; less often - stomatitis, flatulence, constipation, vomiting, sensation of stomach overflow; rarely - nausea, erosive and ulcerative lesions of the gastrointestinal tract (including abdominal pain, spasm or burning in the epigastric region, melena, vomiting like "coffee grounds", nausea, heartburn and others) with perforation and / or bleeding; Cholestatic jaundice, hepatitis, hepatomegaly, acute pancreatitis.
From the urinary system: rarely acute renal failure, back pain with or without hematuria and / or azotemia, haemolytic uremic syndrome (hemolytic anemia, renal failure, thrombocytopenia, purpura), frequent urination, increased or decreased urine volume, nephritis, edema of renal genesis.
From the sense organs: rarely - hearing loss, ringing in the ears, visual impairment (including blurred vision).
From the respiratory system: rarely - bronchospasm, rhinitis, laryngeal edema (shortness of breath, difficulty breathing).
From the central nervous system: often - headache, dizziness, drowsiness; rarely - aseptic meningitis (fever, severe headache, convulsions, neck and / or neck stiffness), hyperactivity (mood changes, anxiety), hallucinations, depression, psychosis.
From the side of the cardiovascular system: less often - increased blood pressure, rarely - pulmonary edema, fainting.
On the part of the organs of hematopoiesis: rarely - anemia, eosinophilia, leukopenia.
From the side of the hemostasis system: rarely bleeding from a postoperative wound, epistaxis, rectal bleeding, exacerbation of ulcerative colitis or Crohn's disease.
From the skin: infrequent skin rash (including maculopapular rash), purpura, rarely exfoliative dermatitis (fever with chills or without, redness, densification or flaking of the skin, swelling and / or tenderness of the tonsils), hives, Stevens-Johnson syndrome, Lyell's syndrome.
Local Reactions: infrequent - burning or pain at the injection site.
Allergic reactions: rarely anaphylaxis or anaphylactoid reactions (discoloration of the face, itching of the skin, tachypnea or dyspnea, edema of the eyelids, periorbital edema, shortness of breath, shortness of breath, heaviness in the chest, wheezing.
Other: often - swelling (face, legs, ankles, fingers, feet, weight gain); infrequently - excessive sweating, rarely - swelling of the tongue, fever.