The frequency of side effects is presented according to the following gradation: very often - more than 10%; often more than 1.0%, but less than 10.0%; infrequently - more than 0,1%, but less than 1,0%; rarely - more than 0.01%, but less than 0.1%; very rarely - less than 0.01%.
From the digestive system: often - gastralgia, diarrhea; stomatitis, flatulence, constipation, vomiting, sensation of stomach overflow; infrequent appetite, nausea, erosive and ulcerative lesions of the gastrointestinal tract (including those with perforation and / or bleeding that can manifest as abdominal pain, spasm or burning in the epigastric region, blood in the feces or melena, vomiting with blood or the type of "coffee grounds", nausea, heartburn, etc.), cholestatic jaundice, hepatitis, hepatomegaly, acute pancreatitis.
From the urinary system: infrequent acute renal failure, back pain, hematuria, azotemia, hemolytic-uremic syndrome (hemolytic anemia, renal failure, thrombocytopenia, purpura), frequent urination,increase or decrease in the volume of urine, nephritis, edema of renal genesis.
From the sense organs: infrequently - hearing loss, ringing in the ears, visual impairment (including blurred vision).
From the respiratory system: infrequently - bronchospasm or shortness of breath, rhinitis, pulmonary edema, laryngeal edema (shortness of breath, difficulty breathing).
From the central nervous system (CNS): often - headache, dizziness, drowsiness; infrequently, aseptic meningitis (fever, severe headache, convulsions, stiff neck and / or back muscles), hyperactivity (mood changes, anxiety), hallucinations, depression, psychosis, fainting.
From the side of the cardiovascular system: often - increased blood pressure, a feeling of heartbeat.
On the part of the organs of hematopoiesis: infrequently, anemia, eosinophilia, and leukopenia.
From the side of the hemostasis system: infrequently - bleeding from a postoperative wound, epistaxis, rectal bleeding.
From the skin: often - skin rash (including maculopapular), purpura; infrequently - exfoliative dermatitis (fever with chills or without, hyperemia, densification or flaky skin,and / or soreness of the tonsils), urticaria, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome).
Local Reactions: often - burning or pain at the injection site.
Allergic reactions: infrequently, anaphylaxis or anaphylactoid reactions (skin discoloration, skin rash, urticaria, skin itching, tachypnea or shortness of breath, eyelid edema, periorbital edema, shortness of breath, shortness of breath, heaviness in the chest, wheezing).
Other: often - swelling (face, legs, ankles, fingers, feet, weight gain), increased sweating; infrequently - swelling of the tongue, fever.