Very often (≥1 / 10), often (≥1 / 100, <1/10), infrequently (≥1 / 1000, <1/100), rarely (≥1 / 10000, <1/1000) and very rarely (<1/10000).
From the digestive system: often - gastralgia, diarrhea, stomatitis, flatulence, constipation, vomiting, sensation of stomach overflow; infrequent appetite, nausea, erosive and ulcerative lesions of the gastrointestinal tract (including perforation and / or bleeding, which can manifest as abdominal pain, spasm or burning in the epigastric region, blood in the feces or melena, vomiting with blood or the type of "coffee grounds", nausea, heartburn, etc.), cholestatic jaundice, hepatitis, hepatomegaly, acute pancreatitis.
From the urinary system: infrequent acute renal failure, back pain, hematuria, azotemia, hemolytic-uremic syndrome (hemolytic anemia, renal insufficiency, thrombocytopenia, purpura), frequent urination, increase or decrease in urine volume, nephritis, edema of renal genesis.
From the sense organs: infrequent - hearing loss, ringing in the ears, impaired vision (including blurred vision).
From the respiratory system: infrequently - bronchospasm or shortness of breath, rhinitis, pulmonary edema, laryngeal edema (shortness of breath, difficulty breathing).
From the central nervous system: often - headache, dizziness, drowsiness; infrequently, aseptic meningitis (fever, severe headache, convulsions, stiff neck and / or back muscles), hyperactivity (mood changes, anxiety), hallucinations, depression, psychosis, fainting.
From the cardiovascular system: often - increased blood pressure, a feeling of palpitations.
From the hematopoiesis: infrequently, anemia, eosinophilia, and leukopenia.
From the side of the hemostasis system: infrequently - bleeding from a postoperative wound, epistaxis, rectal bleeding.
From the skin: often - skin rash (including maculopapular rash), purpura; infrequently - exfoliative dermatitis (fever, chills or without hyperemia, sealing or flaking skin, increase and / or tenderness of the tonsils), urticaria, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome).
Local reactions: often - burning or pain at the injection site.
Allergic reactions: infrequently - anaphylaxis or anaphylactoid reaction (change in skin color, skin rash, hives, itchy skin, tachypnea and dyspnea, edema of the eyelids, periorbital edema, shortness of breath, heaviness in the chest, wheezing).
Other: often - swelling (face, legs, ankles, fingers, feet, weight gain), increased sweating; infrequently - swelling of the tongue, fever.