Sodium bicarbonate - instructions for use, doses, side effects, contraindications

A means for restoring the acid-base state of blood and correcting metabolic acidosis. During the dissociation of sodium bicarbonate, a hydrocarbonate anion is released, binding hydrogen ions to form carbonic acid, which then decomposes into water and exhaled carbon dioxide. As a result, the pH of the blood shifts to the alkaline side, the acid buffer capacity of blood increases. The drug also increases the excretion of sodium and chlorine ions from the body, increases osmotic diuresis, alkalinizes urine, preventing precipitation of uric acid salts in the urinary tract. Inside the cells, the hydrocarbonate anion does not penetrate.

Indications:

Uncompensated metabolic acidosis with various diseases, such as intoxications of various etiologies, extensive burns, shock, diabetic coma, prolonged diarrhea, indomitable vomiting, acute massive blood loss, severe liver and kidney damage, prolonged febrile conditions, severe hypoxia of newborns, postoperative period.

Absolute indication is a decrease in blood pH below 7.2 (the rate of 7.37 - 7.42).

Contraindications:

Metabolic alkalosis, hypersensitivity, hypokalemia, hypernatremia.

Carefully:during pregnancy, during lactation.

Pregnancy and lactation:carefully

Dosing and Administration:

Intravenously drip. Depending on the severity of acidosis apply undiluted or diluted in a 0.9% solution of sodium chloride or 5% glucose solution. Adults 50-100 ml 4 % solution. Children, depending on age and body weight - 3 to 8 ml / kg (2-5 mEq / kg), the dose is administered within 4-8 hours.

For children under 2 years - the maximum dose of 13 ml (8 mEq) per kg of body weight per day.

It is necessary to control the acid-base state of the blood.

Side effects:

With daily long-term use of intravenous drips of 150-200 ml can develop alkalosis: decreased appetite, belching, nausea, vomiting, anxiety, headache, abdominal pain, tetanic convulsions, increased blood pressure. In these cases, you should take a break in the use of the drug.

Overdose:

With an increase in the dose, it is possible to develop decompensated alkalosis, tetanic convulsions. With the development of alkalosis, stop the injection of the drug, with the risk of developing seizures, intravenously calcium gluconate.

Interaction:

In a solution of sodium bicarbonate it is impossible to dissolve acidic substances (ascorbic, nicotinic and other acids), alkaloids (atropine, apomorphine, caffeine, theobromine, papaverine and etc.), cardiac glycosides, salts of calcium, magnesium, heavy metals (iron, copper, zinc), t. precipitation occurs, or hydrolysis of organic compounds. Do not mix with phosphate-containing solutions. May enhance the effect of antihypertensive drugs.

Special instructions:

When using the drug, it is necessary to control the acid-base state of the blood.

In patients with concomitant diseases of the heart or kidneys, heart failure and edema can develop.

Effect on the ability to drive transp. cf. and fur:During drug treatment, it is necessary to abandon the management of vehicles and potentially dangerous mechanisms.

Form release / dosage:

Solution for infusions 40 mg / ml.

Per 100, 200, 400 ml in bottles glass for blood, transfusion and infusion preparations, ukuporennye rubber stoppers and crimped aluminum caps. Bottle together with instruction for use placed in a pack of cardboard.

For hospitals: 35 bottles of 100 ml, 28 bottles of 200 ml or 15 bottles of 400 ml together with an equal amount instructions for use are placed in the boxes of corrugated cardboard with gaskets, with partitions or with lattices ("nests") without preliminary stacking in packs.

Packaging:bottles for blood and blood substitutes (1) -pacples from cardboard (100)
bottles for blood and blood substitutes (1) -packs of cardboard (200)
bottles for blood and blood substitutes (1) -packs of cardboard (400)
bottles for blood and blood substitutes (15) boxes made of corrugated cardboard
bottles for blood and blood substitutes (28) boxes made of corrugated cardboard
bottles for blood and blood substitutes (35) boxes made of corrugated cardboard

Storage conditions:

At a temperature of 15 to 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after expiry date.

Terms of leave from pharmacies:On prescription

Registration number:LSR-003973/10

Date of registration:06.05.2010

The owner of the registration certificate:DALHIMFARM, OJSC DALHIMFARM, OJSC Russia

Manufacturer: & nbsp

DALHIMFARM, OJSC Russia

Information update date: & nbsp26.04.2012

Illustrated instructions

Instructions

Sodium bicarbonate (Sodium hydrocarbonate)