Sodium bicarbonate-Eskom (Sodium hydrocarbonate-Eskom)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceSodium bicarbonateSodium bicarbonate
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    solution d / infusion 
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    • Dosage form: & nbspsolution for infusions
    Composition:

    Sodium bicarbonate 50 g.

    Water for injections up to 1 liter.

    Ionic composition: Na + 595, 25 mmol / l 13.69 g / l

    NSOs3- 595, 25 mmol / l 36.31 g / l

    Description:Transparent colorless liquid.
    Pharmacotherapeutic group:An antacidemic agent
    ATX: & nbsp

    B.05.B.B   Solutions affecting the water-electrolyte balance

    Pharmacodynamics:

    A means for restoring the acid-base state of blood and correcting metabolic acidosis. In the dissociation of sodium bicarbonate, a bicarbonate anion that binds hydrogen ions is liberated to form a carboxylic acid, which then decomposes into water and exhaled carbon dioxide.As a result, the pH of the blood shifts to the alkaline side, the buffer capacity of the blood increases. The drug also increases the excretion of sodium and chlorine ions from the body, increases osmotic diuresis, alkalinizes urine, preventing precipitation of uric acid salts in the urinary system. Inside the cells, the bicarbonate anion does not penetrate.

    Indications:

    Uncompensated metabolic acidosis with various diseases, such as intoxications of various etiologies, extensive burns, shock, diabetic coma, prolonged diarrhea, indomitable vomiting, acute massive blood loss, severe liver and kidney damage, prolonged febrile conditions, severe hypoxia of newborns, postoperative period.

    Absolute indication is a decrease in blood pH below 7.2 (the rate of 7.37 - 7.42).
    Contraindications:

    Metabolic alkalosis, hypersensitivity, hypokalemia, hypernatremia.

    Carefully:

    Pregnancy, lactation.

    Dosing and Administration:

    Intravenously drip. Depending on the severity of acidosis apply undiluted or diluted in a 0.9% solution of sodium chloride or 5% glucose solution).

    Adults with 50-100 ml of 5% solution.Children, depending on their age and body weight - from 3 to 8 ml / kg (2-5 mEq / kg), the dose is administered within 4-8 hours.

    For children under 2 years - the maximum dose of 13 ml (8 mEq) per kg of body weight per day. It is necessary to control the acid-base state of the blood.

    Side effects:

    Nausea, vomiting, anorexia, abdominal pain, headache, anxiety, increased blood pressure.

    Overdose:

    When the dose is exceeded, development of decompensated alkalosis, tetanic convulsions is possible.

    With the development of alkalosis, stop the injection of the drug, with the risk of developing seizures, intravenously calcium gluconate.

    Interaction:

    In a solution of Sodium Hydrocarbonate-Eskom it is impossible to dissolve acidic substances (ascorbic, nicotinic and other acids), alkaloids (atropine, apomorphine, caffeine, theobromine, papaverine and others), cardiac glycosides, salts of calcium, magnesium, heavy metals (iron, copper, zinc), t. precipitation occurs, or hydrolysis of organic compounds. Do not mix with phosphate-containing solutions. May enhance the effect of antihypertensive drugs.

    Special instructions:

    When using the drug, it is necessary to control the acid-base state of the blood.In patients with concomitant diseases of the heart or kidneys, heart failure and edema can develop.

    Form release / dosage:

    Solution for infusions 5.%.

    Packaging:

    For 100, 200 and 400 ml in glass bottles for blood, transfusion and infusion preparations, with a capacity of 100, 250 and. 450 ml respectively.

    For 1 bottle with instructions for the medical use of pomptsot in a pack of cardboard.

    For 28 bottles with a capacity of 100, 250 ml or 15 bottles with a capacity of 450 ml with the appropriate number of instructions for the use of the use placed in a cardboard box (for hospitals).

    Storage conditions:In the dark place at a temperature of not less than 8 ° C. Keep out of the reach of children.
    Shelf life:

    2 years. Do not use the drug after the expiration date.

    Terms of leave from pharmacies:On prescription
    Registration number:LSR-002106/08
    Date of registration:26.03.2008
    Expiration Date:Unlimited
    The owner of the registration certificate:ESKOM NPK, OAO ESKOM NPK, OAO Russia
    Manufacturer: & nbsp
    Information update date: & nbsp24.05.2018
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