Sodium bicarbonate (Sodium hydrocarbonate)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceSodium bicarbonateSodium bicarbonate
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    • Dosage form: & nbsp

    solution for infusions

    Composition:

    Active substance: sodium bicarbonate - 50 g;

    Excipients: disodium edetate dihydrate - 0.2 g, water for injection - up to 1 liter

    Description:Colorless transparent liquid
    Pharmacotherapeutic group:Regulator of acid-base balance
    ATX: & nbsp

    B.05.B.B   Solutions affecting the water-electrolyte balance

    Pharmacodynamics:

    A means for restoring the acid-base state of blood and correcting metabolic acidosis. In the dissociation of sodium bicarbonate, a bicarbonate anion that binds hydrogen ions is liberated to form a carboxylic acid, which then decomposes into water and exhaled carbon dioxide.As a result, the pH of the blood shifts to the alkaline side, the buffer capacity of the blood increases. The drug also increases the excretion of sodium and chlorine ions from the body, increases osmotic diuresis, alkalinizes urine, preventing precipitation of uric acid salts in the urinary system. Inside the cells, the bicarbonate anion does not penetrate.

    Indications:

    Uncompensated metabolic acidosis in various diseases, such as intoxication of various etiologies, extensive burns, shock, diabetic coma, prolonged diarrhea, indomitable vomiting, acute massive blood loss, severe liver and kidney damage, prolonged febrile conditions, severe hypoxia of newborns, postoperative period. Absolute index is a decrease in blood pH below 7.2 (the rate of 7.37-7.42).

    Contraindications:

    Hypersensitivity, metabolic alkalosis, hyponatremia and hypokalemia.

    Carefully:

    Pregnancy, lactation.

    Pregnancy and lactation:

    It is necessary to evaluate the risk and benefit, since sodium hydrogen carbonate can cause systemic alkalosis.

    Dosing and Administration:

    Intravenously drip.Depending on the severity of acidosis apply undiluted or diluted in a 0.9% solution of sodium chloride or 5% glucose solution.

    Adults with 50-100 ml of 5% solution. Children, depending on their age and body weight - from 3 to 8 ml / kg (2-5 mEq / kg), the dose is administered within 4-8 hours.

    For children under 2 years - the maximum dose of 13 ml (8 mEq) per kg of body weight per day.

    It is necessary to control the acid-base state of the blood.

    Side effects:

    Nausea, vomiting, anorexia, abdominal pain, headache, anxiety, increased blood pressure.

    Overdose:

    When the dose is exceeded, development of decompensated alkalosis, tetanic convulsions is possible.

    With the development of alkalosis, stop the injection of the drug, with the risk of developing seizures, intravenously calcium gluconate.

    Interaction:

    In a solution of sodium bicarbonate it is impossible to dissolve acidic substances (ascorbic, nicotinic and other acids), alkaloids (atropine, apomorphine, caffeine, theobromine, papaverine and others), cardiac glycosides, salts of calcium, magnesium, heavy metals (iron, zinc, copper), as precipitation occurs, or hydrolysis of organic compounds. Do not mix with phosphate-containing solutions.May enhance the effect of antihypertensive drugs.

    Special instructions:

    In patients with concomitant diseases of the heart or kidneys, excessive use of sodium ions causes edema and heart failure. When using the drug, it is necessary to control the acid-base state of the blood.

    Effect on the ability to drive transp. cf. and fur:Data on the negative impact of the drug on the performance of potentially hazardous activities requiring special attention and quick reactions (driving and other vehicles, working with moving mechanisms, dispatcher and operator work) are not available.
    Form release / dosage:

    Solution for infusions 50 mg / ml.

    Packaging:

    100,200, 400 ml in glass bottles for blood, infusion and transfusion preparations with a capacity of 100,250 and 450 ml respectively, sealed with rubber plugs and crimped with aluminum caps. Each bottle, together with the instruction for use, is placed in a pack of cardboard for consumer containers.

    56 bottles of 100 ml, 24, 28 bottles with a capacity of 250 ml, and 12, 15 bottles with a capacity of 450 ml, respectively, are placed in boxes of corrugated cardboard with an attachment instructions for the use of appropriatenumber of bottles (for hospitals).

    100, 200, 250, 400, 500, 1000 ml into polyolefin packages.

    56 bags of 100 ml, 24.28 packets of 200 or 250 ml and 12.15 packs of 400 or 500 ml, 12 1000 ml packets are placed in boxes of cardboard corrugated together with instructions for use in an amount corresponding to the number of packages (for hospitals).

    Storage conditions:

    In a place protected from light and inaccessible to children at a temperature of no higher than 25 ° C.

    Shelf life:

    2 years. Do not use after expiry date.

    Terms of leave from pharmacies:On prescription
    Registration number:PL-000812
    Date of registration:04.10.2011 / 13.10.2015
    Expiration Date:04.10.2016
    The owner of the registration certificate:Promomed Rus, Open CompanyPromomed Rus, Open Company Russia
    Manufacturer: & nbsp
    Information update date: & nbsp24.05.2018
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