Active substanceCholine alfoscerateCholine alfoscerate
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  • Dosage form: & nbspcapsules
    Composition:

    Each capsule contains:

    Active substance: choline alfoscerate - 400 mg;

    Excipients: glycerol-50 mg, purified water -140 mg;

    Capsule shell composition: gelatin - 152 mg, ezitol - 41 mg, sorbitan - 33 mg, ethyl parahydroxybenzoate sodium - 0.8 mg, propyl parahydroxybenzoate sodium - 0.4 mg, titanium dioxide (E 171) - 2.4 mg, iron oxide dye yellow (E 172) -1.1 mg.

    Description:Oval yellow opaque soft gelatin capsules containing a viscous colorless solution
    Pharmacotherapeutic group:Nootropic remedy
    ATX: & nbsp

    N.07.A.X.02   Choline alfoscerate

    Pharmacodynamics:Choline alfoscerate (L-α-glycerylphosphorylcholine) is a prodrug from which choline precursor acetylcholine is released by hydrolysis. The latter is an agonist of all subtypes of cholinergic receptors.
    Choline alphoscerate contains 40.5% choline by weight, released from the compound in the brain; Choline is involved in the biosynthesis of acetylcholine, is the donor of methyl groups,participates in other plastic reactions in the body. Alphoscerate ion is metabolized to the glycerophosphate ion.
    Acetylcholine directly participates in the transmission of the nerve impulse in both the central and peripheral nervous system. Glycerophosphate is included in various metabolic pathways, including participates in the synthesis of phosphatidylcholine (one of the phospholipids of cell membranes). Thus, the drug acts on the cholinergic transmission of the nerve impulse, the plasticity of the neuron membrane.
    It is assumed that the drug reduces cognitive impairment in degenerative and vascular lesions of the brain (including cerebrovascular insufficiency and some forms of dementia).
    Pharmacokinetics:Absorption on intake - 88%. Penetrates through the blood-brain barrier (concentration in the brain - 45% of that in the plasma). Both choline and glycerophosphate ion are included in the total metabolism, therefore it is not possible to trace their real elimination from the body. However, it is known that they are metabolized to carbon dioxide, water, phosphates and nitrogen-containing products.
    Indications:
    As part of complex therapy:
    - Psycho-organic syndrome in the background of degenerative diseases and involuntary processes of the brain or cerebrovascular insufficiency, including primary and secondary senile cognitive impairment.
    - Multi-infarct dementia.
    Contraindications:Hypersensitivity to the components of the drug, hemorrhagic stroke (acute stage), pregnancy, breastfeeding, children's age.
    Pregnancy and lactation:
    The use of the drug during pregnancy and breastfeeding is contraindicated.
    Dosing and Administration:Capsules are taken orally before meals, with water, 1 capsule (400 mg) 3 times a day. The duration of therapy is 3-6 months.
    Side effects:
    From the digestive system: gastritis, peptic ulcer, constipation, diarrhea, dryness of the oral mucosa, pharyngitis.
    From the nervous system: headache, drowsiness, insomnia, aggressiveness, nervousness, cerebral ischemia, convulsions, hyperkinesia, dizziness.
    From the skin: rash.
    Other: increased frequency of urination, allergic reactions.
    Overdose:
    There is no information about overdose.
    When an overdose is shown: gastric lavage, taking adsorption drugs (for example, activated charcoal), symptomatic therapy. The effectiveness of dialysis is not established.
    Interaction:Drug interaction is not established.
    Effect on the ability to drive transp. cf. and fur:Care should be taken when driving vehicles or engaging in other activities that require increased concentration and / or speed of psychomotor reactions.
    Form release / dosage:Capsules of 400 mg.
    Packaging:For 14 capsules in PVC / aluminum blister. 1 blister together with instructions for use in a pack of cardboard.
    Storage conditions:At a temperature of no higher than 25 ° C. Keep out of the reach of children.
    Shelf life:3 years. Do not use after expiry date.
    Terms of leave from pharmacies:On prescription
    Registration number:LP-001536
    Date of registration:27.02.2012
    Expiration Date:27.02.2017
    The owner of the registration certificate:ITF, LLC ITF, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp23.03.2017
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