Cholitilin - instructions for use, dose, side effects, contraindications

One capsule contains: active substance: choline alfoscerate hydrate (L-α-glycerophosphorylcholine), in terms of choline, alpha-phosphate 400 mg; Excipients: Purified water 109 mg, Povidone (Plasdon C-15 or Kollidon® 17 PF) 1 mg, macrogol (polyethylene glycol 400) until the mass of the contents of the capsule is 640 mg;

capsule soft gelatinous 250 mg, including: gelatin 164.313 mg, glycerol (glycerol) 41.09 mg, methyl parahydroxybenzoate 1.166 mg, propyl parahydroxybenzoat 0.146 mg, sorbitol 41.5 mg, titanium dioxide 0.674 mg, iron dye oxide yellow 0.77 mg, color iron oxide red 0,154 mg, dye iron oxide black 0.169 g, purified water * (* - noin the finished product).

Description:

Soft gelatin capsules oval in shape, brown.

The contents of capsules are oily, clear, colorless or slightly colored liquid.

Pharmacotherapeutic group:Nootropic agent.

ATX: & nbsp

N.07.A.X.02 Choline alfoscerate

Pharmacodynamics:

Nootropic agent. Central cholinostimulator, which contains 40.5% of metabolically protected choline.

Provides the synthesis of acetylcholine and phosphatidylcholine in neuronal membranes, improves blood flow and enhances metabolic processes in the central nervous system, activates the reticular formation. Increases the linear velocity of blood flow, contributes to the normalization of spatiotemporal characteristics of spontaneous bioelectric activity of the brain, regression of focal neurological symptoms and restoration of consciousness; has a positive effect on the cognitive and behavioral responses of patients with cerebral vascular diseases (discirculatory encephalopathy and residual phenomena of cerebral circulation disorders).

Provides a preventive and corrective effect on the pathogenetic factors of the involutionary psychoorganic syndrome, reduces cholinergic activity. Stimulates the dose-dependent release of acetylcholine under physiological conditions; participating in the synthesis of phosphatidylcholine (membrane phospholipid), improves synoptic transmission, plasticity of neuronal membranes. Has no effect on the reproductive cycle and does not have a teratogenic, mutagenic effect.

Pharmacokinetics:

Absorption - 88%.Easily penetrates the blood-brain barrier (with oral intake, the concentration in the brain is 45% of that in the plasma). It is mainly excreted in the lungs, in the form of carbon dioxide (85%), as well as by the kidneys and through the intestine (15%).

Indications:

In complex therapy with:

- craniocerebral trauma with predominantly stem lesion level (acute period);

- cerebrovascular insufficiency;

- psycho-organic syndrome on the background of degenerative diseases and involuntary processes of the brain;

- multi-infarct dementia.

Contraindications:Hypersensitivity, hemorrhagic stroke (acute stage), pregnancy, lactation, children under 18 years.

Dosing and Administration:

Inside, 0.4 g 3 times a day, for 3-6 months.

In the subacute period of craniocerebral trauma of 0.8 g in the morning and 0.4 g in the afternoon for 6 months.

Side effects:

From the digestive system: gastritis, peptic ulcer, pharyngitis.

From the nervous system: nervousness, cerebral ischemia, convulsions, hyperkinesia, dizziness.

Other: allergic reactions, frequent urination.

Interaction:Drug interaction of the drug is not established.

Special instructions:During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Form release / dosage:Capsules, 400 mg.

Packaging:

For 14 capsules in a contour mesh box made of polyvinylchloride film and aluminum foil

printed lacquered.

For 1, 2, 3, 4 contour packs of 14 capsules together with instructions for use in a pack

from cardboard for consumer packaging.

Packing at the enterprise of CJSC "Canonfarma Production": on 10 or 14 capsules in a contour cellular package from a film of polyvinylchloride and a foil of an aluminum printed varnished.

For 1, 2, 3, 4 contour packs of 10 or 14 capsules together with instructions for use in a pack of cardboard for consumer containers.

Storage conditions:

In a dry, protected from light place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LSR-004850/10

Date of registration:28.05.2010

The owner of the registration certificate:ARTLIFE, LLC ARTLIFE, LLC Russia

Manufacturer: & nbsp

ARTLIFE, LLC Russia

Information update date: & nbsp26.09.2015

Illustrated instructions

Instructions

Holilitil (Cholitilin)