Active substanceCholine alfoscerateCholine alfoscerate
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  • Dosage form: & nbspSolution for intravenous and intramuscular injection.
    Composition:

    active substance: choline alfoscerate hydrate (in terms of choline alphoscerate) - 250.0 mg;

    auxiliary substance: water for injection - up to 1.0 ml.

    Description:Transparent colorless or slightly yellowish liquid.
    Pharmacotherapeutic group:Nootropic agent.
    ATX: & nbsp

    N.07.A.X.02   Choline alfoscerate

    Pharmacodynamics:
    Nootropic agent. Central cholinostimulator in the composition

    '

    which contains 40.5% of the metabolically protected choline. Metabolic protection contributes to the release of choline in the brain.

    Provides the synthesis of acetylcholine and phosphatidylcholine in neuronal membranes, improves blood flow and enhances metabolic processes in the central nervous system, activates the reticular formation. Increases the linear velocity of blood flow on the side of traumatic brain injury, promotes normalization of spatiotemporal characteristics of spontaneous bioelectrical activity of the brain,regress of focal neurological symptoms and restoration of consciousness; has a positive effect on the cognitive and behavioral responses of patients with cerebral vascular diseases (discirculatory encephalopathy and residual phenomena of cerebral circulation disorders).
    Provides a preventive and corrective effect on pathogenetic factors of the involutionary psychoorganic syndrome, changes the phospholipid composition of neuronal membranes and reduces cholinergic activity. Stimulates the dose-dependent release of acetylcholine under physiological conditions; participating in the synthesis of phosphatidylcholine (membrane phospholipid), improves synaptic transmission, plasticity of neuronal membranes, receptor function. Has no effect on the reproductive cycle and does not have a teratogenic, mutagenic effect.
    Pharmacokinetics:
    Easily penetrates the blood-brain barrier.
    It is mainly excreted in the lungs, in the form of carbon dioxide (85%), as well as by the kidneys and through the intestine (15%).
    Indications:Craniocerebral injury with predominantly stem lesion level (acute period), cerebrovascular insufficiency,psycho-organic syndrome on the background of degenerative diseases and involution processes of the brain, multi-infarct dementia.
    Contraindications:Hypersensitivity to the components of the drug, hemorrhagic stroke (acute stage), pregnancy, the period of breastfeeding, children's age.
    Dosing and Administration:The drug is administered intravenously (slowly) or intramuscularly, 1 g (1 ampoule) per day for 15-20 days.
    Side effects:

    From the digestive system: constipation, diarrhea, dryness of the oral mucosa, pharyngitis.

    From the nervous system: headache, drowsiness, insomnia, aggressiveness, anxiety, nervousness, dizziness.

    From the skin: a rash, hives.

    Other: pain in the injection site, frequency of urination.

    Overdose:
    Symptoms: nausea.
    Treatment: symptomatic.
    Interaction:Significant interaction with other drugs has not been established.
    Effect on the ability to drive transp. cf. and fur:Given the potential for side effects, patients during treatment should be careful in managing vehicles and other mechanisms,requiring increased concentration of attention and speed of psychomotor reactions.
    Form release / dosage:Solution for intravenous and intramuscular injection 250 mg / ml.
    Packaging:
    4 ml into neutral glass ampoules.
    3.5 or 10 ampoules per contour cell pack of a polyvinyl chloride film.
    1 circuit cell pack with instructions for use and a scarifier or a knife ampoule in a pack of cardboard.
    When using ampoules with a ring or break point, the scarifier or ampoule knife is not inserted.
    Storage conditions:In the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.
    Shelf life:
    5 years. Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LP-001431
    Date of registration:12.01.2012
    Date of cancellation:2017-01-12
    The owner of the registration certificate:Company DEKO, LLC Company DEKO, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp26.09.2015
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