Choline alfoscerate - instructions for use, dose, side effects, contraindications

Choline alphoscerate as a carrier of choline and a precursor of phosphatidylcholine has the potential to prevent and correct biochemical damage that is of particular importance among the pathogenetic factors of the psychoorganic involution syndrome, that is, it can affect the decrease in cholinergic transmission and the damaged phospholipid composition of the nerve cell membranes. The chemical formula of choline alphoscerate (containing 40.5% of choline) has the property of metabolic protection and provides the release of the active substance - choline in the brain tissues. Choline alfoscerate positively affects memory functions and cognitive abilities, as well as on the indicators of emotional state and behavior, the deterioration of which was caused by the development of involuntary pathology of the brain.

Pharmacokinetics:

The pharmacokinetic characteristics of a radioactive labeled preparation were similar in different animal species (rats, dogs, monkeys) and consisted in the following: absorption from the gastrointestinal tract was complete and rapid; rapid accumulation and distribution in various organs and tissues, including the brain; renal excretion is about 10%, for 96 hours of the administered dose); the concentration of the drug is higher in the brain, in comparison with the choline marked with tritium.

Indications:

- Psychoorganic syndrome on the background of involutional and degenerative processes in the brain;

- the consequences of cerebrovascular insufficiency or primary and secondary cognitive impairment in the elderly, characterized by memory impairment, confusion, disorientation, decreased motivation and initiative, decreased concentration of attention;

- impaired behavior and affective sphere in the old age: emotional lability, increased irritability, decreased interest;

- senile pseudomelanchia.

Contraindications:

Hypersensitivity to choline alfoscerate or to the components of the drug, as well as to drugs with a similar chemical structure.

Pregnancy and the period of breastfeeding.

Children under 18 years.

Pregnancy and lactation:

The drug is contraindicated during pregnancy and during breastfeeding.

Dosing and Administration:

Intramuscularly or intravenously.

Intramuscularly (slowly) or intravenously (drip) at a dose of 1000 mg / day.

With intravenous administration, the contents of one ampoule (4 ml) are diluted in 50 ml of 0.9% sodium chloride solution, the infusion rate is 60-80 drops per minute. The duration of treatment is usually 10 days. If necessary, the treatment can be continued according to the prescription of the doctor depending on the clinical picture and features of the course of the disease, age and tolerability of the drug. Then, after stabilizing the patient's condition, they switch to oral dosage forms. Doses may be increased at the discretion of the attending physician.

Children. The experience of the use of choline in patients with alfoscerate is absent.

Side effects:

From the digestive system: nausea (which is mainly a consequence of secondary dopaminergic activation), abdominal pain.

From the nervous system: short-term confusion (in this case, you need to reduce the dose of the drug).

Overdose:

It is possible to increase the severity of dose-dependent side effects.

Treatment: symptomatic therapy. The effectiveness of dialysis is not established.

Interaction:

Clinically significant interaction of the drug with other drugs has not been established.

Special instructions:

Nausea can result from dopaminergic activation.

Efficacy and safety in children under 18 years of age is not established.

Effect on the ability to drive transp. cf. and fur:

During the treatment period, care must be taken when driving vehicles and engaging in potentially hazardous activities requiring increased attention and speed of psychomotor reactions.

Form release / dosage:

Solution for intravenous and intramuscular injection, 250 mg / ml.

Packaging:

By 4 ml into ampoules of colorless neutral glass type I with a colored break ring or with a colored dot and a notch or without a kink ring, a colored dot and a notch. Ampoules can additionally be applied one, two or three color rings and / or a two-dimensional bar code,and / or alphanumeric encoding or without additional color rings, a two-dimensional barcode, alphanumeric encoding.

5 ampoules per circuit cell packaging made of polyvinylchloride film and aluminum foil foil or polymer film or without foil and without film. Or 5 ampoules are placed in a prefabricated form (tray) made of cardboard with cells for laying ampoules.

1 or 2 contour squares or cardboard trays along with the instruction for use and a scarifier or a knife with an ampoule, or without a scarifier and an ampoule knife are placed in a cardboard package.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C. Do not freeze.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LP-003816

Date of registration:31.08.2016

Expiration Date:31.08.2021

The owner of the registration certificate:ATOLL, LLC ATOLL, LLC Russia

Manufacturer: & nbsp

OZONE, LLC Russia

Representation: & nbspOZONE LLC OZONE LLC Russia

Information update date: & nbsp20.10.2016

Illustrated instructions

Instructions

Choline alfoscerate (Choline alfoscerate)