Choline alfoscerate - instructions for use, dose, side effects, contraindications

Choline alphoscerate as a carrier of choline and a precursor of phosphatidylcholine has the potential to prevent and correct biochemical damage that is of particular importance among the pathogenetic factors of the psychoorganic involution syndrome, that is, it can affect the decrease in cholinergic transmission and the damaged phospholipid composition of the nerve cell membranes. The chemical formula of choline alphoscerate (containing 40.5% of choline) has the property of metabolic protection and provides the release of the active substance - choline in the brain tissues.

Choline alfoscerate positively affects memory functions and cognitive abilities, as well as on the indicators of emotional state and behavior, the deterioration of which was caused by the development of involuntary pathology of the brain.

Pharmacokinetics:

The pharmacokinetic characteristics of the radiolabeled drug were similar in different animal species (rats, dogs, monkeys), as follows: absorption from the gastrointestinal tract completely and quickly; rapidly accumulates and is distributed in various organs and tissues, including the brain; renal excretion is about 10%, for 96 hours of the administered dose); the concentration of the drug is higher in the brain, in comparison with choline, labeled with tritium.

Indications:

Psycho-organic syndrome against the background of involuntary and degenerative processes in the brain, the consequences of cerebrovascular insufficiency or primary and secondary cognitive impairment in the elderly, characterized by memory impairment, confusion, disorientation, decreased motivation and initiative, decreased concentration of attention.

Violations of behavior and affective sphere in old age: emotional lability,increased irritability, decreased interest.

An old pseudo-melancholy.

Contraindications:

Hypersensitivity to choline alfoscerate or auxiliary components of the drug.

Pregnancy, the period of breastfeeding; childhood.

Pregnancy and lactation:

The use of the drug during pregnancy and breastfeeding is contraindicated.

Dosing and Administration:

The drug is administered intramuscularly or intravenously (drip, slowly) at a dose of 1000 mg (1 ampoule) per day for 10 days.

Doses and duration of treatment, if necessary and good tolerability can be increased by the attending physician depending on the clinical picture, the features of the course of the disease, the age and tolerability of the drug.

If unwanted reactions appear, a temporary dose reduction is possible (see the "Side effect" section).

Children. The experience of using the drug in children is absent.

Side effects:

Perhaps the emergence of nausea (which is mainly a consequence of secondary dopaminergic activation), very rarely possible abdominal pain and short-term confusion. In this case, it is necessary to reduce the used dose of the drug.

Overdose:There is no information about overdose.

In case of an overdose, symptomatic therapy is indicated. The effectiveness of dialysis is not established.

Interaction:

Drug interaction is not established.

Effect on the ability to drive transp. cf. and fur:

Care should be taken when driving vehicles or engaging in other activities that require increased concentration and / or speed of psychomotor reactions.

Form release / dosage:

Solution for intravenous and intramuscular injection, 250 mg / ml.

Packaging:

To 4 ml in ampoules with a capacity of 5 ml of glass.

5 ampoules together with a knife or scarifier for opening ampoules and instructions for medical use in a pack with a cardboard insert for fixing ampoules.

5 ampoules in a blister pack. 2 blister packs with ampoules together with a knife or scarifier for opening ampoules and instructions for medical use in a pack of cardboard.

10 ampoules together with a knife or scarifier for opening ampoules and instructions for medical use in a cardboard box.

In the case of using ampoules with a kink ring or a notch and a break point,The insertion of a knife or scarifier for opening ampoules is not provided.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LP-003768

Date of registration:08.08.2016

Expiration Date:08.08.2021

The owner of the registration certificate:BORISOVSKIY FACTORY OF MEDPREPARATES, OJSC BORISOVSKIY FACTORY OF MEDPREPARATES, OJSC Republic of Belarus

Manufacturer: & nbsp

BORISOVSKIY FACTORY OF MEDPREPARATES, OJSC Republic of Belarus

Representation: & nbspBORISOVSKIY FACTORY OF MEDPREPARATES, OJSCBORISOVSKIY FACTORY OF MEDPREPARATES, OJSC

Information update date: & nbsp08.10.2016

Illustrated instructions

Instructions

Choline alfoscerate (Choline alfoscerate)