Choline alfoscerate - instructions for use, dose, side effects, contraindications

Choline alphoscerate as a carrier of choline and a precursor of phosphatidylcholine has the potential to prevent and correct biochemical damage that is of particular importance among the pathogenetic factors of the psychoorganic involution syndrome, that is, it can affect the decrease in cholinergic transmission and the damaged phospholipid composition of the nerve cell membranes. The chemical formula of choline alphoscerate (containing 40.5% of choline) has the property of metabolic protection and provides the release of the active substance - choline in the brain tissues. Choline alfoscerate positively affects memory functions and cognitive abilities, as well as on the indicators of emotional state and behavior, the deterioration of which was caused by the development of involuntary pathology of the brain.

Pharmacokinetics:

The pharmacokinetic characteristics of a radioactive labeled preparation were similar in different species of animals (rats, dogs, monkeys), are as follows: suctionfrom the gastrointestinal tract completely and quickly; rapidly accumulates and is distributed in various organs and tissues, including the brain; renal excretion is about 10%, for 96 hours of the administered dose); drug concentration higher in the brain, in comparison with choline, labeled with tritium.

Indications:

Psycho-organic syndrome in the background of involuntary and degenerative processes in the brain, the consequences of cerebrovascular insufficiency or primary and secondary cognitive impairment in the elderly, characterized by memory impairment, confusion, disorientation, decreased motivation and intensity, decreased concentration of attention.

Violations of behavior and affective sphere in old age: emotional lability,increased irritability, decreased interest.

An old pseudo-melancholy.

Contraindications:

Hypersensitivity to choline alfoscerate or auxiliary components of the drug.

Pregnancy, the period of breastfeeding; childhood.

Pregnancy and lactation:

Application of the drug during pregnancy and breastfeeding it is contraindicated.

Dosing and Administration:

The drug is administered intramuscularly or intravenously (drip, slowly) at a dose of 1000 mg (1 ampoule) per day for 10 days.

The dose and duration of treatment, if necessary and well tolerated, can be increased by the attending physician depending on the clinical picture, the features of the course of the disease, the age and tolerability of the drug.

If unwanted reactions appear, a temporary dose reduction is possible (see the "Side effect" section).

Children. Experience with the drug Choline alfoscerate children are absent.

Side effects:

Perhaps the emergence of nausea (which is mainly a consequence of secondary dopaminergic activation), very rarely possible abdominal pain and short-term confusion.In this case, it is necessary to reduce the used dose of the drug.

Overdose:

There is no information on overdose.

In case of an overdose, symptomatic therapy is indicated. The effectiveness of dialysis is not installed.

Interaction:

Drug interaction is not established.

Effect on the ability to drive transp. cf. and fur:

Care should be taken when driving vehicles or engaging in other activities that require increased concentration and / or speed of psychomotor reactions.

Form release / dosage:

Solution for intravenous and intramuscular injection, 250 mg / ml.

Packaging:

By 4 ml into ampoules, 5 ml capacity, from neutral glass of the 1st class or neutral stack of the grade HC-3.

5 ampoules per contour cell pack.

On 1 contour acheikova packing together with the instruction on application in a pack from a cardboard.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LP-003771

Date of registration:10.08.2016

Expiration Date:10.08.2021

The owner of the registration certificate:PharmIntelekt, OOOPharmIntelekt, OOO Russia

Manufacturer: & nbsp

Armavir Biofactory, FKP

Representation: & nbspPharmIntelekt, OOOPharmIntelekt, OOORussia

Information update date: & nbsp07.09.2016

Illustrated instructions

Instructions

Choline alfoscerate (Choline alfoscerate)