Tsereton - instructions for use, dose, side effects, contraindications

Choline alphoscerate is a cholinomimetic of central action with a predominant effect on the central nervous system. The composition of the drug includes 40.5% of choline released from the compound in the brain; Choline is involved in the biosynthesis of acetylcholine (one of the main neurotransmitter mediators). Alphoscerate is biotransformed to glycerophosphate, which is a precursor of phospholipids.Acetylcholine positively affects the transmission of nerve impulses, and glycerophosphate is involved in the synthesis of phosphatidylcholine (membrane phospholipid), resulting in improved membrane elasticity and receptor function. Choline alfoscerate strengthens metabolic processes and activates the structures of the reticular formation of the brain. Provides a preventive and corrective effect on the factors of involuntary psychoorganic syndrome, such as changes in the phospholipid composition of neuronal membranes and a decrease in cholinergic activity. Pharmacodynamic studies have shown that choline alphoscerate acts on synaptic, including cholinergic transmission of the nerve impulse (neurotransmission), plasticity of the neuronal membrane; function of receptors.

Pharmacokinetics:

Rapidly absorbed, on average about 88% of the administered dose of choline is absorbed, rapid distribution in organs and tissues is noted. Penetrates through the blood-brain barrier. The drug accumulates mainly in the brain (concentration in the brain is 45% of that in the plasma), lungs and liver. Renal excretion is about 10%.

Indications:

Psycho-organic syndrome against the background of involuntary and degenerative processes in the brain, the consequences of cerebrovascular insufficiency, or primary and secondary cognitive impairment, including in the elderly, characterized by memory impairment, confusion, disorientation, decreased motivation and initiative, decreased concentration of attention. Violations of behavior and affective sphere in elderly and senile age: emotional lability, increased irritability, decreased interest. An old pseudo-melancholy. Multi-infarct dementia.

Contraindications:

Hypersensitivity to the components of the drug, pregnancy, breastfeeding, children and adolescents under 18 (due to lack of data).

Pregnancy and lactation:

The use of the drug during pregnancy and during breastfeeding is contraindicated.

Dosing and Administration:

Inside before eating, washed down with water, 5 ml (600 mg) 2 times a day. Duration of treatment the doctor determines individually, depending on the clinical picture and features of the course of the disease, age and tolerability of the drug.

Side effects:

From the digestive system: nausea (which is mainly a consequence of secondary dopaminergic activation), abdominal pain.

From the nervous system: short-term confusion (in this case, you need to reduce the dose of the drug).

Overdose:

It is possible to increase the severity of dose-dependent side effects.

Treatment: symptomatic therapy, taking adsorption drugs (for example, activated carbon). The effectiveness of dialysis is not established.

Interaction:

Clinically significant interaction with other drugs has not been established.

Special instructions:

Nausea can result from dopaminergic activation.

The effectiveness and safety of the drug in children and adolescents under 18 years is not established.

Effect on the ability to drive transp. cf. and fur:

During the use of the drug, care should be taken when administering

transport or when engaging in other activities that require an increased concentration of attention and / or speed of psychomotor reactions.

Form release / dosage:

Solution for oral administration, 600 mg / 5 ml.

Packaging:

To 100 ml in bottles of brown glass, sealed with screw caps made of plastic with the control of the first opening.

1 bottle complete with a measuring spoon made of plastic and instructions for use in a pack of cardboard.

Storage conditions:

At a temperature of no higher than 25 ° C. Do not freeze.

Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LP-004829

Date of registration:26.04.2018

Expiration Date:26.04.2023

The owner of the registration certificate:FarmSirma Soteks, ZAO FarmSirma Soteks, ZAO Russia

Manufacturer: & nbsp

FarmSirma Soteks, ZAO Russia

Information update date: & nbsp28.05.2018

Illustrated instructions

Instructions

Cereton® (Cereton)