Nokholin Rhompharm - instructions for use, dose, side effects, contraindications

Cholinomimetic of central action with a predominant effect on the central nervous system. The drug contains 40.5% of metabolically protected choline. Choline alfoscerate in the body under the influence of brain enzymes is split into choline and glycerophosphate. Choline is involved in the synthesis of acetylcholine, transmitting nerve impulses and improving the work of the brain, and glycerophosphate is a precursor of phosphatidylcholine membranes of neurons.

Choline alphoscerate improves cerebral blood flow, enhances metabolic processes in the brain, activates the structures of the reticular formation of the brain and restores consciousness in traumatic brain lesions.

The results of clinical trials demonstrated that choline alphoscerate stimulates the dose-dependent release of acetylcholine in the physiological conditions of neurotransmission.

The drug does not have a teratogenic and mutagenic effect.

Pharmacokinetics:Easily penetrates into various tissues and organs, including the brain. Excreted mainly lungs in the form of carbon dioxide (85%), excreted by the kidneys and through the intestine

15 %.

Indications:An acute period of craniocerebral trauma with predominantly stem lesion level; psychoorganic syndrome in the background of degenerative and involuntary changes in the brain; consequences of cerebrovascular insufficiency (impaired mental function); multi-infarct dementia.

Contraindications:Hypersensitivity, hemorrhagic stroke (acute stage).

Pregnancy and lactation:The use of the drug during pregnancy and lactation period is contraindicated. For the duration of treatment, breastfeeding should be discontinued.

Dosing and Administration:Intramuscularly and intravenously (slowly), 1.0 g / day, for 15-20 days, then switch to oral intake.

Side effects:

From the digestive system: constipation, diarrhea, dryness of the oral mucosa, pharyngitis.

From the nervous system: headache, drowsiness, insomnia, aggressiveness, anxiety, nervousness, cerebral ischemia, dizziness.

From the skin: rash, hives.

Other: pain in the injection site, frequency of urination.

Overdose:

Symptoms: in the case of an overdose, nausea occurs, which occurs after a reduction in dose or discontinuation of treatment.

Treatment: symptomatic therapy.

Interaction:Clinically significant drug interaction of choline with alpha-phosphate was not detected with other drugs.

Special instructions:

Children under the age of 18 years should be appointed only after a preliminary assessment of the general state of health.

If nausea occurs, reduce the dose of Noocholine Rompharm.

Effect on the ability to drive transp. cf. and fur:Noochlin Rhompharm does not affect the speed of psychomotor reactions.

Form release / dosage:Solution for intravenous and intramuscular administration of 250 mg / ml.

Packaging:

By 4.0 ml of the drug in colorless ampoules with a capacity of 5 ml of hydrolytic class I glass with a kink ring. A label is affixed to each ampoule.For 3 or 5 ampoules are placed in contoured cell packs. On 1 contour acheikova packing together with the instruction on application place in a cardboard pack.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Inaccessible to children!

Shelf life:

4 years.

Do not use after the expiration date stated on the package!

Terms of leave from pharmacies:On prescription

Registration number:PL-000715

Date of registration:29.09.2011

Date of cancellation:2016-09-29

The owner of the registration certificate:K.O. Ромфарм Компани С.Р.Л.K.O. Ромфарм Компани С.Р.Л. Romania

Manufacturer: & nbsp

S.C. ROMPHARM Company, S.R.L. Romania

Representation: & nbspРомфарма ОООРомфарма ООО

Information update date: & nbsp26.09.2015

Illustrated instructions

Instructions

Noochlin Rompharm (Nooholin Romfarm)