Delecite - instructions for use, doses, side effects, contraindications

Choline alphoscerate (L-α-glycerylphosphorylcholine) is a prodrug from which choline precursor acetylcholine is released by hydrolysis. The latter is an agonist of all subtypes of cholinergic receptors.

Choline alphoscerate contains 40.5% choline by weight, released from the compound in the brain; Choline participates in the biosynthesis of acetylcholine, is the donor of the methyl groups, and participates in other plastic reactions in the body. Alphoscerate ion is metabolized to the glycerophosphate ion.

Acetylcholine directly participates in the transmission of the nerve impulse in both the central and peripheral nervous system.Glycerophosphate is included in various metabolic pathways, including participates in the synthesis of phosphatidylcholine (one of the phospholipids of cell membranes). Thus, the drug acts on the cholinergic transmission of the nerve impulse, the plasticity of the neuron membrane.

It is assumed that the drug reduces cognitive impairment in degenerative and vascular lesions of the brain (including cerebrovascular insufficiency and some forms of dementia).

Pharmacokinetics:

Penetrates through the blood-brain barrier (concentration in the brain -45% of that in the plasma). Both choline and glycerophosphate ion are included in the total metabolism, therefore it is not possible to trace their real elimination from the body. However, it is known that they are metabolized to carbon dioxide, water, phosphates and nitrogen-containing products.

Indications:

As part of complex therapy:

- Psycho-organic syndrome in the background of degenerative diseases and involuntary processes of the brain or cerebrovascular insufficiency, including primary and secondary senile cognitive impairments.

- Multi-infarct dementia.

Contraindications:Hypersensitivity to choline alfoscerate, hemorrhagic stroke (acute stage), pregnancy, breastfeeding, children's age.

Pregnancy and lactation:The use of the drug during pregnancy and breastfeeding is contraindicated.

Dosing and Administration:

The drug is administered intramuscularly or intravenously (drip). A solution for infusion and intramuscular injection is used in acute conditions or inability to take the drug inside.

Enter intramuscularly or intravenously (drip) at a dose of 1000 mg (1 ampoule) per day. With intravenous administration, the contents of one ampoule (4 ml) are diluted in 50 ml of 0.9% sodium chloride solution; the infusion rate is 60-80 drops per minute. The duration of treatment is usually 10 days, then switch to taking the drug inside. The general course of treatment with the drug is 3-6 months.

Side effects:

From the digestive system: constipation, diarrhea, dryness of the oral mucosa, pharyngitis.

From the nervous system: headache, drowsiness, insomnia, aggressiveness, anxiety, nervousness, cerebral ischemia, dizziness.

From the skin: rash, hives.

Other: pain at the injection site, frequent urination, allergic reactions.

Overdose:

There is no information about overdose.

In case of an overdose, symptomatic therapy is indicated. The effectiveness of dialysis is not established.

Interaction:Drug interaction is not established.

Effect on the ability to drive transp. cf. and fur:Care should be taken when driving vehicles or engaging in other activities that require increased concentration and / or speed of psychomotor reactions.

Form release / dosage:Solution for infusion and intramuscular injection 1000 mg / 4 ml.

Packaging:

For 4 ml of solution in ampoules of neutral colorless glass type I.

For 3 or 5 ampoules per contour cell pack together with instructions for use in a cardboard pack.

Storage conditions:

At a temperature of no higher than 25 ° C in a dark place.

Keep out of the reach of children!

Shelf life:2 years. Do not use after expiry date.

Terms of leave from pharmacies:On prescription

Registration number:LP-001577

Date of registration:07.03.2012

Expiration Date:07.03.2017

The owner of the registration certificate:ITF, LLC ITF, LLC Russia

Manufacturer: & nbsp

BIOLOGICI ITALIA Laboratories, S.R.L. Italy

Information update date: & nbsp23.03.2017

Illustrated instructions

Instructions

Delecite (Delecit)