Dimexide - instructions for use, doses, side effects, contraindications

Anti-inflammatory drug for external use, inactivates hydroxyl radicals, improves the course of metabolic processes in the focus of inflammation. It also has local anesthetic, analgesic and antimicrobial effects; has moderate fibrinolytic activity. Penetrates through the skin, mucous membranes, the membrane of microbial cells (increases their sensitivity to antibiotics) and other biological membranes, increases their permeability for medicines.

Pharmacokinetics:

When applying a solution of dimethyl sulfoxide on the skin, it is found in the blood after 5 minutes, reaching a maximum concentration in 4-6 hours, while maintaining an almost unchanged level for 1.5-3 days. Dimethisulphoxide is excreted in urine and feces, both in unmodified form and in the form of dimethyl sulfone.

Indications:In the complex therapy: diseases of the musculoskeletal system: rheumatoid arthritis, ankylosing spondylitis (Bekhterev's disease), deforming osteoarthritis (in the presence of lesions of periarticular tissues), reactive synovitis; limited scleroderma, erythema nodosum, discoid lupus erythematosus, mycosis stop, keloid scars,thrombophlebitis, alopecia, eczema, erysipelas; bruises, sprains, traumatic infiltrates; purulent wounds, burns, sciatica, trophic ulcers, acne, furunculosis, in skin and plastic surgery - canning of skin homotransplants.

Contraindications:

Hypersensitivity to dimethylsulfoxide, severe hepatic and / or renal failure, angina pectoris, severe atherosclerosis, glaucoma, cataract, stroke, coma, myocardial infarction, childhood, pregnancy, breast-feeding period.

Dosing and Administration:

Nakozhno, in the form of appliqués and irrigation (washing). In a solution of the necessary concentration, gauze wipes are moistened and applied to the affected areas within 20-30 minutes. A polyethylene film and cotton or linen cloth are applied over the napkin. The duration of the application is 10-15 days.

When treating erysipelas and trophic ulcers - in the form of 30-50% solution of 50-100 ml 2-3 times a day.

With eczema - compresses with 40-90% solution.

For local anesthesia with pain syndromes - 25-50% solution in the form of compresses of 100-150 ml 2-3 times a day.

10-20-30% solutions are used for facial skin and other highly sensitive areas.

In skin and plastic surgery in 5% solution in Ringer's solution is used as the preservative medium for storage of skin homotransplants.

Less concentrated solutions produce washing of purulent-necrotic and inflammatory foci and cavities.

Side effects:

Allergic reactions, contact dermatitis, erythema, dry skin, mild burning, itchy dermatitis, bronchospasm.

Overdose:

Symptoms: increased dose-related side effects.

Treatment is symptomatic.

Interaction:Increases absorption and enhances the action of ethanol, insulin and other medicines. Compatible with heparin, antibacterial agents, non-steroidal anti-inflammatory drugs. Increases the sensitivity of microorganisms to aminoglycosides and beta-lactam antibiotics; chloramphenicol, rifampicin, griseofulvin.

Special instructions:

Some patients feel the smell of garlic in the inspired air.

Before using the drug, it is necessary to carry out a test for tolerance to it. For this dimethylsulfoxide apply to the skin with a cotton swab soaked in it; the appearance of hyperemia and pronounced itching indicates a hypersensitivity.

Effect on the ability to drive transp. cf. and fur:

The effect on the ability to drive vehicles and mechanisms has not been studied. Care must be taken when driving vehicles and engaging in potentially dangerous activities that require increased concentration and speed of psychomotor reactions.

Form release / dosage:Concentrate for the preparation of solution for external use 50 and 100 ml.

Packaging:

50 ml and 100 ml in bottles of orange glass with a label sealed with a stopper and lid. One bottle with instructions in a pack of cardboard.

Storage conditions:

Store in a dry place protected from light.

Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LS-002242

Date of registration:10.02.2012

The owner of the registration certificate:REDKINSKY EXPERIMENTAL FACTORY, CJSC REDKINSKY EXPERIMENTAL FACTORY, CJSC Russia

Manufacturer: & nbsp

REDKINSKY EXPERIMENTAL FACTORY, CJSC Russia

Information update date: & nbsp05.01.16

Illustrated instructions

Instructions

Dimexide (Dimexid)