Active substanceDimethylsulfoxideDimethylsulfoxide
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  • Dosage form: & nbspconcentrate for solution for external use
    Composition:

    Per 100 ml:

    Active substance:

    Dimexide (dimethylsulfoxide) - 100 ml.

    Description:

    Colorless, clear liquid or colorless crystals, odorless or with a weak characteristic odor. Hygroscopic.

    Pharmacotherapeutic group:Anti-inflammatory agent for topical application
    ATX: & nbsp

    M.02.A.X.03   Dimethylsulfoxide

    G.04.B.X.13   Dimethylsulfoxide

    Pharmacodynamics:

    Anti-inflammatory drug for external use, inactivates hydroxyl radicals, improves the course of metabolic processes in the focus of inflammation.

    It also has local anesthetic, analgesic and antimicrobial action; has moderate fibrinolytic activity.

    Penetrates through the skin, mucous membranes, the shell of microbial cells (increases their sensitivity to antibiotics) and other biological membranes, increases their permeability to drugs.

    Indications:

    In the complex therapy: diseases of the musculoskeletal system: rheumatoid arthritis, ankylosing spondylitis (Bekhterev's disease), deforming osteoarthritis (in the presence of periarticular tissue damage), reactive synovitis, limited scleroderma, nodal erythema, discoid lupus erythematosus, mycosis feet, keloid scars, thrombophlebitis, alopecia, eczema, streptoderma, erysipelas; bruises, sprains, traumatic infiltrates; purulent wounds, burns, radiculitis, trophic ulcers, acne, furunculosis, in skin and plastic surgery - for canning dermal gomotransplants.

    Contraindications:

    Hypersensitivity, severe hepatic and / or renal failure, angina pectoris, severe atherosclerosis, glaucoma, cataract, stroke, coma, myocardial infarction, pregnancy, the period of breastfeeding.

    Children under the age of twelve should not be appointed.

    Pregnancy and lactation:

    The use of the drug during pregnancy and during breastfeeding is contraindicated.

    Dosing and Administration:

    Outwardly, in the form of appliqués and irrigation (washing).

    In a solution of the necessary concentration, gauze wipes are moistened and applied to the affected areas during 20-30 min. A polyethylene film and cotton or linen cloth are applied over the napkin. Duration of applications 10-15 days.

    When treating erysipelas and trophic ulcers - in the form of 30-50% solution in water by 50-100 ml 2-3 times a day.

    With eczema, streptodermia - compresses with 40-90% solution in water.

    For local anesthesia with pain syndromes - 25-50% solution in water from of compresses by 100-150 ml (depending on the area to be treated) 2-3 times a day.

    For facial skin and other highly sensitive areas apply 10-20-30% solutions in water.

    In skin and plastic surgery dressings are used with 20-30% solution on transplanted cutaneous auto- and gomotransplants immediately after surgery and on subsequent days of the postoperative period until the transplant is permanently engrafted.

    In skin and plastic surgery, as a preservative medium for the storage of skin homotransplants, 5% solution in Ringer's solution.

    Less concentrated solutions produce washing of purulent-necrotic and inflammatory foci and cavities.

    Side effects:

    Allergic reactions, contact dermatitis, erythematous rashes, dry skin, mild burning, itchy dermatitis, bronchospasm.

    Overdose:

    Symptoms: increased dose-dependent side effects.

    Treatment - symptomatic.

    Interaction:

    Increases absorption and enhances the effect of ethanol (alcohol inhibits the elimination of the drug), insulin (with long-term use of the drug monitor the glucose in blood plasma) and other medicines.

    Compatible with heparin, antibacterial agents, non-steroidal anti-inflammatory drugs.

    Increases the sensitivity of microorganisms to aminoglycoside and beta-lactam antibiotics; chloramphenicol, rifampicin,griseofulvin.

    It sensitizes the body to medicines for general anesthesia.

    Special instructions:

    Some patients feel the smell of garlic in the inspired air.

    Before using the drug, it is necessary to carry out a test for tolerance to it. For this dimethylsulfoxide the desired concentration is applied to the skin with a cotton swab soaked in it; the appearance of hyperemia and pronounced itching indicates a hypersensitivity.

    When stored at a temperature of 18 ° C or lower, the dimethyl sulfoxide crystallizes, which does not affect the quality of the preparation. To melt crystals, you should gently warm the bottle with the drug in a water bath (water temperature not higher than 60 ° C).

    Effect on the ability to drive transp. cf. and fur:

    The use of the drug in accordance with the instruction does not affect the management of vehicles and occupations of potentially hazardous activities requiring increased concentration of attention and speed of psychomotor reactions.

    Form release / dosage: Concentrate for the preparation of solution for external use, 99%.
    Packaging:

    To 50 ml, 100 ml in bottles of dark glass, sealed with stoppers, plastic caps and caps screwed or caps screw-on.

    To 100 ml in bottles of dark glass, ukuporennye caps aluminum.

    To 100 ml in bottles-dropper polymer complete with a cap screwed and stopper-dropper.

    100 ml in bottles of polyethylene terephthalate with the means of corking or in bottles made of polyethylene, capped with polypropylene lids.

    Each bottle, together with the instructions for use, is placed in a pack of cardboard. It is possible to put the full text of the instruction on the pack.

    It is allowed to pack 30 bottles or 60 pieces without a pack together with an equal number of instructions for use in a box of corrugated cardboard or a cardboard box (For hospitals).

    For 1 liter, 3 liters, 5 liters, 10 liters, 20 liters in polyethylene cans of low-density polyethylene (For hospitals).

    Storage conditions:

    In the dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:LP-004005
    Date of registration:07.12.2016
    Expiration Date:07.12.2021
    The owner of the registration certificate:KEMEROVSKAYA PHARMACEUTICAL FACTORY, OJSC KEMEROVSKAYA PHARMACEUTICAL FACTORY, OJSC Russia
    Manufacturer: & nbsp
    Representation: & nbspKEMEROVSKAYA PHARMACEUTICAL FACTORY, OJSCKEMEROVSKAYA PHARMACEUTICAL FACTORY, OJSC
    Information update date: & nbsp16.01.2017
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