Active substanceDimethylsulfoxideDimethylsulfoxide
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    ROSFARM, LLC     Russia
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    MARBIOFARM, OJSC     Russia
  • Dimexide
    concentrate cutaneous 
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    concentrate cutaneous 
  • Dimexide
    concentrate externally 
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    YUZHFARM, LLC     Russia
  • Dosage form: & nbsp

    concentrate for solution for external use.

    Composition:

    Dimexide - 100 ml

    Description:Colorless transparent liquid or colorless crystals without a smell or with a weak specific odor. Hygroscopic.
    Pharmacotherapeutic group:anti-inflammatory for topical use.
    ATX: & nbsp

    M.02.A.X.03   Dimethylsulfoxide

    G.04.B.X.13   Dimethylsulfoxide

    Pharmacodynamics:

    Anti-inflammatory drug for external use, inactivates hydroxyl radicals, improves the course of metabolic processes in the focus of inflammation. It also has local anesthetic, analgesic and antimicrobial effects; has moderate fibrinolytic activity.

    Penetrates through the skin, mucous membranes of the microbial cells (increases their sensitivity to antibiotics), and other biological membranes, increases their permeability for medicines.

    Indications:

    As part of complex therapy: diseases of the musculoskeletal system: rheumatoid arthritis, Bekhterev's disease (ankylosing spondylitis), deforming osteoarthritis, reactive synovitis; Organic scleroderma, nodular erythema, discoid lupus erythematosus, tinea pedis, keloid scars, thrombophlebitis, alopecia, eczema, erysipelas, bruises, sprains, traumatic infiltrates; purulent wounds, burns, sciatica, trophic ulcers, acne, furunculosis.

    In skin and plastic surgery - preservation of skin homotransplant.
    Contraindications:

    Hypersensitivity, severe hepatic and / or renal failure, angina pectoris, severe atherosclerosis, glaucoma, cataract,stroke, coma, myocardial infarction, pregnancy, lactation.

    Dosing and Administration:

    Outwardly, in the form of appliqués and irrigation (washing). In a solution of the necessary concentration, gauze wipes are moistened and applied to the affected areas within 20-30 minutes. A polyethylene film and cotton or linen cloth are applied over the napkin. The duration of the application is 10-15 days.

    When treating erysipelas and trophic ulcers - in the form of 30-50% solution of 50-100 ml 2-3 times a day.

    With eczema, diffuse streptodermia - compresses with 40-90% solution.

    For local anesthesia with pain syndromes - 25-50% solution in the form of compresses of 100-150 ml 2-3 times a day.

    For the skin of the face and other highly sensitive areas 10-20-30% solutions are used.

    When treating deep burns apply bandages with 20-30% dimexide solution (if necessary, in a dose of up to 500 ml).

    In skin and plastic surgery, bandages with 10-20% solution are applied to transplanted cutaneous auto- and homotransplantants immediately after operations and on subsequent days of the postoperative period until the transplant is permanently engrafted.

    As a preserving medium for storing skin homotransplants, 5% solution is used in Ringer's solution.

    Less concentrated solutions produce washing of purulent necrotic and inflammatory foci and cavities.

    Side effects:

    Allergic reactions, contact dermatitis, erythema, dry skin, mild burning, itchy dermatitis; rarely - bronchospasm.

    Interaction:Increases absorption and enhances the action of ethanol, insulin and other medicines. Compatible with heparin, antibacterial agents, NSAIDs. Increases the sensitivity of microorganisms to aminoglycoside and beta-lactam antibiotics; chloramphenicol, rifampicin, griseofulvin.
    Special instructions:

    Some patients feel the smell of garlic in the inspired air.

    Before using the drug, it is necessary to carry out a test for tolerance to it.

    For this, dimethyl sulfoxide is applied to the skin with a cotton swab soaked in it; the appearance of hyperemia and pronounced itching indicates a hypersensitivity.

    Form release / dosage:Concentrate for the preparation of a solution for external use, 990 mg / ml.
    Packaging:

    Concentrate for the preparation of a solution for external use in orange glass vials of 50 or 100 ml. Each bottle together with instructions for use place a pack of cardboard.

    Storage conditions:

    In a dry place, protected from light and out of reach of children, at a temperature not exceeding 25 ° C.

    Shelf life:

    2 years. Do not use after the expiration date indicated on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LS-000910
    Date of registration:05.07.2010
    The owner of the registration certificate:MARBIOFARM, OJSC MARBIOFARM, OJSC Russia
    Manufacturer: & nbsp
    Representation: & nbspMARBIOFARM, OJSCMARBIOFARM, OJSC
    Information update date: & nbsp05.01.16
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