Active substanceDimethylsulfoxideDimethylsulfoxide
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  • Dosage form: & nbspConcentrate for the preparation of solution for external use.
    Composition:Dimexide (dimethylsulfoxide) - 50, 100 ml.
    Description:Colorless transparent liquid or colorless crystals without a smell or with a weak specific odor. Hygroscopic.
    Pharmacotherapeutic group:Anti-inflammatory for topical use.
    ATX: & nbsp

    M.02.A.X.03   Dimethylsulfoxide

    G.04.B.X.13   Dimethylsulfoxide

    Pharmacodynamics:

    Anti-inflammatory drug for external use, inactivates hydroxyl radicals, improves the course of metabolic processes in the focus of inflammation. It also has local anesthetic, analgesic and antimicrobial action; has moderate fibrinolytic activity. Penetrates through the skin, mucous membranes, the shell of microbial cells (increases their sensitivity to antibiotics) and other biological membranes, increases their permeability to drugs.

    Pharmacokinetics:

    When applying a solution of dimethyl sulfoxide on the skin, it is found in the blood after 5 minutes, reaching a maximum concentration in 4-6 hours, while maintaining an almost unchanged level for 1.5-3 days. Dimethylsulfoxide excreted in urine and feces, both in unmodified form and in the form of dimethylsulfone.

    Indications:

    As part of complex therapy: diseases of the musculoskeletal system: rheumatoid arthritis, ankylosing spondylitis (Bekhterev's disease), deforming osteoarthritis (in the presence of lesions of periarticular tissues), reactive synovitis; limited scleroderma, erythema nodosum, discoid lupus erythematosus, mycosis stop,keloid scars, thrombophlebitis, alopecia, eczema, streptoderma, erysipelas; bruises, sprains, traumatic infiltrates; purulent wounds, burns, radiculitis, trophic ulcers, acne, furunculosis, in skin and plastic surgery - for canning dermal gomotransplants.

    Contraindications:

    Hypersensitivity, severe hepatic and / or renal failure, angina pectoris, severe atherosclerosis, glaucoma, cataract, stroke, coma, myocardial infarction, pregnancy, the period of breastfeeding.

    Pregnancy and lactation:

    The use of the drug during pregnancy and during breastfeeding is contraindicated.

    Dosing and Administration:

    Nakozhno, in the form of appliqués and irrigation (washing). In a solution of the necessary concentration, gauze wipes are moistened and applied to the affected areas in within 20-30 minutes. A polyethylene film and cotton or linen cloth are applied over the napkin. The duration of the application is 10-15 days.

    When treating erysipelas and trophic ulcers - in the form of 30-50% solution in water 50-100 ml 2-3 times a day.

    With eczema, streptodermia - compresses with 40-90% solution in water.

    For local anesthesia with pain syndromes - 25-50% solution in water in the form of compresses of 100-150 ml (depending on the treated area) 2-3 times a day.For the face skin and other highly sensitive areas, 10-20-30% solutions in water are used.

    In skin and plastic surgery dressings with 20-30% solution are applied to transplanted cutaneous auto- and gomotransplants immediately after the operations and in the subsequent days of the postoperative period until the transplant is permanently engrafted. In skin and plastic surgery, a 5% solution in Ringer's solution is used as a preservative medium for storing skin homotransplants.

    Less concentrated solutions produce washing of purulent-necrotic and inflammatory foci and cavities.

    Side effects:

    Allergic reactions, contact dermatitis, erythematous rashes, dry skin, mild burning, itchy dermatitis, bronchospasm.

    Overdose:Symptoms: increased dose-related side effects. Treatment is symptomatic.
    Interaction:Increases absorption and enhances the effect of ethanol (alcohol inhibits the elimination of the drug), insulin (with long-term use of the drug monitor the glucose in blood plasma) and other medicines. Compatible with heparin, antibacterial agents, non-steroidal anti-inflammatory drugs.Increases the sensitivity of microorganisms to aminoglycoside and beta-lactam antibiotics; chloramphenicol, rifampicin, griseofulvin. It sensitizes the body to medicines for general anesthesia.
    Special instructions:

    Some patients feel the smell of garlic in the inspired air.

    Before using the drug, it is necessary to carry out a test for tolerance to it. For this dimethylsulfoxide the desired concentration is applied to the skin with a cotton swab soaked in it; the appearance of hyperemia and pronounced itching indicates a hypersensitivity.

    When stored at a temperature of 18 ° C or lower, the dimethyl sulfoxide crystallizes, which does not affect the quality of the preparation. To melt the crystals, you should gently warm the vial with the drug in a water bath (water temperature not higher than 60 ° C).

    Effect on the ability to drive transp. cf. and fur:The use of the drug does not affect the performance of potentially hazardous activities requiring special attention and quick reactions (vehicle management, work with moving mechanisms).
    Form release / dosage:Concentrate for the preparation of solution for external use 99%.
    Packaging:

    For 50 and 100 ml of the drug in orange glass bottles with a screw mouth, sealed with polyethylene plugs and screw caps; or ukuporennyh caps are capping-screwed.

    For 50 and 100 ml in bottles of imported brown glass, ukuporennyh polyethylene caps with the control of the first autopsy.

    Each bottle, together with the instructions for use, is placed in a pack of cardboard. The full text of the instructions for use should be applied to the pack.

    Storage conditions:

    In a dry, protected from light place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after the expiration date.
    Terms of leave from pharmacies:Without recipe
    Registration number:LP-002703
    Date of registration:10.11.2014
    The owner of the registration certificate:IVANOVSKAYA Pharmaceutical Factory, OAO IVANOVSKAYA Pharmaceutical Factory, OAO Russia
    Manufacturer: & nbsp
    Information update date: & nbsp05.01.16
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