Dimexide - instructions for use, doses, side effects, contraindications

Auxiliary substances: methyl parahydroxybenzoate (nipagine) 0.050 g, propyl parahydroxybenzoate (nipazole) 0.013 g, carmellose sodium (sodium carboxymethylcellulose) 2.0 g, water purified to 100.0 g

Description:

Colorless or yellowish tinge transparent gel with a weakspecific odor.

Pharmacotherapeutic group:Anti-inflammatory drug for external use.

ATX: & nbsp

M.02.A.X.03 Dimethylsulfoxide

G.04.B.X.13 Dimethylsulfoxide

Pharmacodynamics:

Anti-inflammatory agent with local analgesic and anti-inflammatory effect. Has a moderate antiseptic and fibrinolytic effect.

Dimethyl sulfoxide inhibits inflammatory tissue infiltration. Besides, dimethylsulfoxide, contributes to the normalization of fibrinogenesis processes. Dimethyl sulfoxide increases microcirculation in tissues, inhibiting aggregation of erythrocytes, increases activity of phagocytes, suppresses chemotaxis of neutrophils and reduces the content of circulating immune complexes. Penetrates through the skin, mucous membranes, the cellular wall of bacteria (increases their sensitivity to antibiotics) and other biological membranes, increases their permeability for medicines. The drug is low toxicity.

Pharmacokinetics:

When the drug is applied dimethylsulfoxide is detected in the blood serum after 8-15 minutes, the maximum content being observed after 2-8 hours.Typically, in 30-36 hours dimethylsulfoxide in the blood serum is no longer detected. Dimethylsulfoxide Do not cumulate. With topical application of the drug dimethylsulfoxide penetrates into the articular cavity, in the blood and tissues it binds to proteins. Dimethylsulfoxide is excreted from the body through the kidneys unchanged and in the form of oxidation products - dimethylsulfone and dimethyl sulfate; as well as in the form of a reduced product (dimethyl sulfide) is released with exhaled air.

Indications:

They are used to relieve the pain syndrome with complex therapy of rheumatoid arthritis, Bechterew's disease, deforming osteoarthritis, arthropathy, radiculitis, trigeminal neuralgia, etc., to treat bruises, ligament damage, traumatic infiltrates, and erythema nodosum therapy.

Contraindications:

Hypersensitivity to Dimexide or other components of the drug, pregnancy, lactation, severe liver and kidney damage, angina pectoris, myocardial infarction, severe atherosclerosis, various types of stroke, glaucoma, cataract, coma, children under 12 years.

Carefully:

Due to the fact that Dimexide can enhance not only the activity, but also the toxicity of some drugs, care should be taken when prescribing it simultaneously with other drugs.

Dosing and Administration:

Outwardly. Adults and children over 12 years of age, the drug is applied a thin layer on the affected area 1-2 times a day. Duration of treatment is 10-14 days. Repeated courses can be conducted not later than 10 days.

Side effects:

In the process of using the drug, contact dermatitis, garlic odor of exhaled air, increased skin pigmentation, allergic reactions, erythematous rashes, dry skin, mild burning sensation can be observed. Some patients do not perceive the smell of the drug (nausea, urge to vomit), in rare cases, bronchospasm is possible.

If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, inform the doctor about it.

Overdose:

Symptoms: increased dose-related side effects. In these cases, the drug should be discarded, the damaged area should be rinsed, and the drug removed.

Interaction:Compatible with heparin, antibacterial drugs, non-steroidal anti-inflammatory drugs (NSAIDs). Increases the sensitivity of microorganisms to aminoglycoside and beta-lactam antibiotics; chloramphenicol, rifampicin, griseofulvin.

Special instructions:Given the possibility of individual intolerance to the drug, it is recommended to carry out a drug test for tolerance to it. For this, a thin layer of gel is applied to the skin of the elbow fold. The appearance of sharp redness and itching indicates hypersensitivity to Dimexide.
If there are allergic reactions during the treatment, the drug is stopped, H1-histamine receptor blockers are prescribed.

Form release / dosage:Gel for external use 25%.

Packaging:

Gel for external use 25% in aluminum tubes for 30 g. Each tube together with the instruction for use is placed in a cardboard box.

Storage conditions:

Store at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years. Do not use after expiry date.

Terms of leave from pharmacies:On prescription

Registration number:PL-000501

Date of registration:01.03.2011 / 07.04.2016

Expiration Date:Unlimited

The owner of the registration certificate:BIOFARMAKS, LLC BIOFARMAKS, LLC Russia

Manufacturer: & nbsp

FARMAMED, LLC Russia

Information update date: & nbsp05.01.16

Illustrated instructions

Instructions

Dimexide (Dimexid)