Active substanceDimethylsulfoxideDimethylsulfoxide
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  • Dosage form: & nbspconcentrate for solution for external use.
    Composition:Dimexide - 100 g
    Description:It is a colorless transparent liquid or colorless crystals without an odor or with a weak specific odor. Hygroscopic.
    Pharmacotherapeutic group:anti-inflammatory for topical use.
    ATX: & nbsp

    M.02.A.X.03   Dimethylsulfoxide

    G.04.B.X.13   Dimethylsulfoxide

    Pharmacodynamics:

    Anti-inflammatory drug for external use, inactivates hydroxyl radicals, improves the course of metabolic processes in the focus of inflammation. It also has local anesthetic, analgesic and antimicrobial effects; has moderate fibrinolytic activity. Penetrates through the skin, mucous membranes of the microbial cells (increases their sensitivity to antibiotics), and other biological membranes, increases their permeability for medicines.

    Indications:

    As part of complex therapy: diseases of the musculoskeletal system: rheumatoid arthritis, Bekhterev's disease (ankylosing spondylitis), deforming osteoarthritis, reactive synovitis; limited scleroderma, nodal erythema, discoid lupus erythematosus, foot mycoses, keloid scars, thrombophlebitis, alopecia, eczema, erysipelas; bruises, sprains, traumatic infiltrates; purulent wounds, burns, radiculitis, trophic ulcers, acne, furunculosis, in the skin surgery - canning of skin homotransplants.

    Contraindications:

    Hypersensitivity, severe hepatic and / or renal failure, angina pectoris, severe atherosclerosis, glaucoma, cataract,stroke, coma, myocardial infarction, pregnancy, lactation.

    Dosing and Administration:

    Nakozhno, in the form of appliqués and irrigation (washing). In a solution of the necessary concentration, gauze wipes are moistened and applied to the affected areas within 20-30 minutes. A polyethylene film and cotton or linen cloth are applied over the napkin. The duration of the application is 10-15 days.

    When treating erysipelas and trophic ulcers - in the form of 30-50% solution of 50-100 ml 2-3 times a day.

    With eczema, diffuse streptodermia - compressors with 40-90% solution.

    For local anesthesia with pain syndromes - 25-50% solution in the form of compresses of 100-150 ml 2-3 times a day.

    For the skin of the face and other highly sensitive areas 10-20-30% solutions are used.

    In skin and plastic surgery, bandages with 10-20% solution are applied to transplanted cutaneous auto- and gomotransplants immediately after operations and on subsequent days of the postoperative period until the transplant is permanently engrafted.

    As preserving medium for storage of skin homotransplants, 5% solution is used in Ringer's solution.

    Less concentrated solutions produce washing of purulent-necrotic and inflammatory foci and cavities.

    Side effects:

    Allergic reactions, contact dermatitis, erythema, dry skin, mild burning, itchy dermatitis; rarely - bronchospasm.

    Interaction:

    Increases absorption and enhances the action of ethanol, insulin and other medicines. Compatible with heparin, antibacterial agents, NSAIDs. Increases the sensitivity of microorganisms to aminoglycoside and beta-lactam antibiotics; chloramphenicol, rifampicin, griseofulvin.

    Special instructions:

    Some patients feel the smell of garlic in the inspired air.

    Before using the drug, it is necessary to carry out a test for tolerance to it. For this dimethylsulfoxide apply to the skin with a cotton swab soaked in it; the appearance of hyperemia and pronounced itching indicates a hypersensitivity.

    Form release / dosage:Concentrate for the preparation of solution for external use.
    Packaging:

    Concentrate for the preparation of a solution for external use 99% in glass vials of OS 100 ml. Each bottle, together with the instructions for use, is placed in a pack of cardboard.

    Storage conditions:

    At a temperature not higher than 25 ° C, out of the reach of children.

    Shelf life:2 years.Do not use after expiry date.
    Terms of leave from pharmacies:On prescription
    Registration number:LSR-001906/08
    Date of registration:18.03.2008
    The owner of the registration certificate:MUROMSKY INSTRUMENT-MAKING PLANT, OJSC MUROMSKY INSTRUMENT-MAKING PLANT, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp05.01.16
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