Inosine-Eskom - instructions for use, dose, side effects, contraindications

Inosine is a derivative (nucleoside) of purine, a precursor of adenosine triphosphate (ATP). Refers to a group of drugs that stimulate metabolic processes. Has antihypoxic and antiarrhythmic effect. Increases the energy balance of the myocardium, improves coronary circulation, prevents the consequences of intraoperative kidney ischemia. It takes a direct part in the exchange of glucose and promotes the activation of metabolism in conditions of hypoxia and in the absence of ATP.

Activates the metabolism of pyruvic acid to ensure a normal process of tissue respiration, and also promotes the activation of xanthine dehydrogenase. Stimulates the synthesis of nucleotides, enhances the activity of certain enzymes of the Krebs cycle. Penetrating into cells, it has a positive effect on the processes of metabolism in the myocardium, increases the strength of the heart contractions and promotes more complete relaxation of the myocardium in diastole, as a result of which the shock volume of blood increases.The mechanism of antiarrhythmic action is not fully understood.

Reduces platelet aggregation, activates the regeneration of tissues (especially the myocardium and mucous membrane of the gastrointestinal tract).

Pharmacokinetics:

Metabolized in the liver with the formation of glucuronic acid and its subsequent oxidation.

In an insignificant amount excreted in the urine.

Indications:

Complex treatment of myocardial infarction, coronary heart disease, cardiac rhythm disorders caused by the use of cardiac glycosides; on the background of myocardial dystrophy after the transferred infectious diseases.

Diseases of the liver (hepatitis, cirrhosis, fatty degeneration).

Operations on an isolated kidney (as a means of pharmacological protection when the circulation is turned off).

Contraindications:

Hypersensitivity to the drug, gout, hyperuricemia, pregnancy, lactation, children under 18 years of age (efficacy and safety not established).

Carefully:With renal failure.

Dosing and Administration:

The drug is used intravenously struino slowly or drip (40-60 drops in 1 minute).Treatment begins with the administration of 200 mg (10 ml of 20 mg / ml solution) once a day, then, with good tolerability, the dose is increased to 400 mg (20 ml of 20 mg / ml solution) 1-2 times a day.

Duration of treatment is 10-15 days.

Jet injection of the drug is possible for acute heart rhythm disorders in a single dose of 200-400 mg.

For pharmacological renal protection subjected to ischemia-ESCOM Inosine administered intravenously in a single dose 1.2 g (60 ml of a 20 mg / ml solution) for 5-15 minutes prior to clamping of the renal artery, then another 0.8 g (40 ml 20 mg / ml solution) immediately after the restoration of blood circulation.

When dripping in a vein of 20 mg / ml solution of the drug is diluted in a 5% solution of dextrose (glucose) or 0.9% solution of sodium chloride (up to 250 ml).

Side effects:

Allergic reactions: skin itching, skin hyperemia (drug should be discarded).

Rarely: increased concentration of uric acid in the blood, exacerbation of gout (with prolonged use).

Special instructions:

When itching and hyperemia of the skin, treatment with the drug should be discarded.

During prolonged treatment it is desirable to control the level of uric acid in the blood and urine.

Form release / dosage:

Solution for intravenous administration, 20 mg / ml.

Packaging:

For 5 ml or 10 ml of the drug in ampoules with a notch or ring of a neutral or neutral lens neutral glass.

For 10 ampoules, together with instructions for medical use and a scarifier, the ampullum is placed in a cardboard bundle with cardboard partitions, or 5 or 10 ampoules are placed in a contour cell box made of a polyvinyl chloride film.

On 1 or 2 contour acheikova packing together with the instruction on application place in a pack from a cardboard.

Storage conditions:In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LSR-007161/09

Date of registration:10.09.2009

Expiration Date:Unlimited

The owner of the registration certificate:ESKOM NPK, OAO ESKOM NPK, OAO Russia

Manufacturer: & nbsp

ESKOM NPK, OAO Russia

Representation: & nbspESKOM NPK, OAOESKOM NPK, OAO

Information update date: & nbsp31.10.2017

Illustrated instructions

Instructions

Inozin-Eskom (Inosine-Eskom)