Active substanceInosineInosine
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  • Dosage form: & nbspcapsules
    Composition:

    1 capsule contains;

    active components: inosine (in terms of 100% substance) 200 mg;

    Excipients: calcium stearate, potato starch;

    composition of gelatin capsule shell: gelatin pharmaceutical, glycerol, methyl parahydroxybenzoate, propyl parahydroxybenzoate, sodium lauryl sulfate, titanium dioxide, dye Red charming E-129, purified water.

    Description:

    Capsules hard gelatinous № 1 red.

    The contents of the capsules are white powder.

    Pharmacotherapeutic group:metabolic
    ATX: & nbsp

    C.01.E.B   Other drugs for the treatment of heart disease

    Pharmacodynamics:

    Riboxin belongs to the group of drugs that regulate metabolic processes. The predecessor of adenosine triphosphate (ATP). Has anti-hypoxic, metabolic and antiarrhythmic effects. Increases the energy balance of the myocardium, improves coronary circulation, prevents the consequences of intraoperative kidney ischemia. It takes a direct part in the exchange of glucose and promotes the activation of metabolism in conditions of hypoxia and in the absence of ATP.

    Activates the metabolism of pyruvic acid to ensure a normal process of tissue respiration, and also promotes the activation of xanthine dehydrogenase. Stimulates the synthesis of nucleotides, enhances the activity of certain enzymes of the Krebs cycle.Penetrating into cells, increases the energy level, has a positive effect on the metabolic processes in the myocardium, increases the strength of the heart contractions and promotes more complete relaxation of the myocardium in diastole, resulting in an increase in the shock volume of blood.

    Reduces platelet aggregation, activates the regeneration of tissues (especially myocardium and gastrointestinal mucosa (GI tract)).

    Pharmacokinetics:

    It is well absorbed in the digestive tract. Metabolised in the liver with the formation of glucuronic acid and its subsequent oxidation. In a small amount is excreted by the kidneys.

    Indications:

    Assign adults in the complex therapy of coronary heart disease, myocardial dystrophy, after myocardial infarction, heart rhythm disorders due to the use of cardiac glycosides.

    Assign with hepatitis, cirrhosis, fatty liver, caused by alcohol or drugs and urocoppororphy.

    Contraindications:

    Hypersensitivity to the components of the drug, gout, hyperuricemia.

    Pregnancy, lactation.

    Age to 18 years.

    Carefully:Renal failure.
    Dosing and Administration:

    Is ingested before meals.In the first days of treatment, the daily dose is 600-800 mg 1 capsule 3-4 times a day). If the drug is well tolerated, the dose is increased (on the 2-3th day) to 1200 mg, (400 mg 3 times a day), if necessary - up to 2,400 mg. The duration of the course is from 4 weeks to 1.5-3 months.

    With urocoppororphy, the daily dose is 800 mg (200 mg 4 times a day).

    Side effects:Allergic reactions are possible in the form of hives, itchy skin, skin hyperemia (drug withdrawal is required).
    Rarely in the treatment of the drug there is an increase in the concentration of uric acid in the blood and exacerbation of gout (with prolonged use).
    Interaction:

    Not found.

    Form release / dosage:

    Capsules, 200 mg.

    Packaging:

    For 10 capsules in a planar cell pack, 5 contour packs with instructions for use in a pack of cardboard box.

    Storage conditions:

    In dry, dark place at a temperature of 15 to 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 of the year.

    Do not use after the expiration date.

    Terms of leave from pharmacies:On prescription
    Registration number:П N015116 / 01
    Date of registration:19.05.2008
    The owner of the registration certificate:MINSKINTERKAPS, UP MINSKINTERKAPS, UP Republic of Belarus
    Manufacturer: & nbsp
    MINSKINTERKAPS, UP Republic of Belarus
    Representation: & nbspMINSKINTERKAPS MINSKINTERKAPS Republic of Belarus
    Information update date: & nbsp23.10.2015
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