Active substanceInosineInosine
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  • Dosage form: & nbspfilm-coated tablets
    Composition:

    Each tablet contains:

    active substance: inosine (riboxin) 200 mg;

    Excipients: potato starch, refined sugar (sucrose),povidone (low molecular weight polyvinylpyrrolidone or plasdon), stearic acid, magnesium stearate;

    composition of film shell: hydroxypropyl cellulose (giprolose), titanium dioxide, talc, polyethylene glycol (macrogol 4000), tropeolin O (dye tropeolin O).

    Description:

    Round tablets, biconvex, covered with a film membrane, from light yellow to yellow-orange color. On the cross-section, two layers are visible, the color of the inner layer is white.

    Pharmacotherapeutic group:metabolic
    ATX: & nbsp

    C.01.E.B   Other drugs for the treatment of heart disease

    Pharmacodynamics:

    Metabolic agent, a precursor of adenosine triphosphate; has antihypoxic, metabolic and antiarrhythmic effects. Increases the energy balance of the myocardium, improves coronary circulation, prevents the consequences of intraoperative kidney ischemia. It takes a direct part in the exchange of glucose and promotes the activation of metabolism in conditions of hypoxia and in the absence of adenosine triphosphate. Activates the metabolism of pyruvic acid to ensure a normal process of tissue respiration, and also promotes the activation of xanthine dehydrogenase.Stimulates the synthesis of nucleotides, enhances the activity of certain enzymes of the Krebs cycle. Penetrating into cells, increases the energy level, has a positive effect on the metabolic processes in the myocardium - increases the strength of the contractions of the heart and promotes more complete relaxation of the myocardium in diastole, resulting in an increased shock volume. Reduces platelet aggregation, activates the regeneration of tissues (especially the myocardium and mucous membrane of the gastrointestinal tract).

    Pharmacokinetics:

    It is well absorbed in the gastrointestinal tract. Metabolised in the liver with the formation of glucuronic acid and its subsequent oxidation. In an insignificant amount is excreted in the urine.

    Indications:

    Assign adults in the complex therapy of coronary heart disease, myocardial dystrophy, after myocardial infarction, heart rhythm disorders due to the use of cardiac glycosides.

    Assign with hepatitis, cirrhosis, fatty liver, caused by alcohol or drugs and urocoppororphy.

    Contraindications:

    Hypersensitivity to the drug, gout, hyperuricemia.

    Carefully:Renal failure.
    Dosing and Administration:

    Assign inside before eating.The daily intake for oral administration is 0.6-2.4 g. In the first days of treatment, the daily dose is 0.6-0.8 g (200 mg 3-4 times a day). In case of good tolerance, the dose is increased (2-3 days) to 1.2 g (400 mg 3 times a day), if necessary - up to 2.4 g per day. The duration of the course is from 4 weeks to 1.5-3 months.

    With urocoppororphy, the daily dose is 0.8 g (200 mg 4 times a day). The drug is taken daily for 1-3 months.

    Side effects:Allergic reactions are possible in the form of hives, itchy skin, skin hyperemia (drug withdrawal is required).
    Rarely in the treatment of the drug raises the concentration of uric acid in the blood and exacerbation of gout (with prolonged use).
    Form release / dosage:Tablets, film-coated, 200 mg.
    Packaging:

    10 tablets per contour cell packaging made of polyvinylchloride film and aluminum foil.

    For 2, 3 or 5 contour mesh packages together with the instruction for use are placed in a pack of cardboard.

    Storage conditions:

    Store in a dry, dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LSR-005042/09
    Date of registration:25.06.2009
    The owner of the registration certificate:BINNOFARM, CJSC BINNOFARM, CJSC Russia
    Manufacturer: & nbsp
    Representation: & nbspBINNOFARM CJSC BINNOFARM CJSC Russia
    Information update date: & nbsp22.10.2015
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