Riboxin - instructions for use, dose, side effects, contraindications

Riboxin is a derivative (nucleoside) of purine, a precursor of adenosine triphosphate (ATP). Refers to a group of drugs that stimulate metabolic processes. Has antihypoxic and antiarrhythmic effect. Increases the energy balance of the myocardium, improves coronary circulation, prevents the consequences of intraoperative kidney ischemia. It takes a direct part in the exchange of glucose and promotes the activation of metabolism under conditions of hypoxia and in the absence of ATP.

Activates the metabolism of pyruvic acid necessary to ensure the normal process of tissue respiration, and also promotes the activation of xanthine dehydrogenase. Stimulates the synthesis of nucleotides, enhances the activity of certain enzymes of the Krebs cycle. It has a positive effect on metabolic processes in the myocardium - it increases the strength of the heart contractions and promotes more complete relaxation of the myocardium in diastole, as a result of which the stroke volume increases. The mechanism of antiarrhythmic action is not fully understood.

Reduces platelet aggregation, activates the regeneration of tissues (especially the myocardium and mucous membrane of the gastrointestinal tract).

Pharmacokinetics:

Metabolised in the liver with the formation of glucuronic acid and its subsequent oxidation. In an insignificant amount excreted in the urine.

Indications:

In complex treatment:

- suffered myocardial infarction;

- ischemic heart disease;

- disorders of the heart rhythm caused by the use of cardiac glycosides, as well as against the background of myocardial dystrophy after the transferred infectious diseases.

Diseases of the liver (hepatitis, cirrhosis, fatty degeneration), urocoppororphyria.

Operations on an isolated kidney (as a means of pharmacological protection when the circulation is turned off).

Contraindications:

- Individual intolerance to inosine or other derivatives of purine, as well as other components of the drug;

- gout;

- Hyperuricemia;

- pregnancy, the period of breastfeeding;

- age under 18 years (efficiency and safety not established).

Carefully:With renal failure.

Pregnancy and lactation:

The drug is contraindicated in pregnancy.

There is no data on the penetration of inosine into breast milk, so if it is necessary to prescribe the drug during lactation, breastfeeding should be discontinued.

Dosing and Administration:

The drug is used intravenously slowly by streaming or by drop (40-60 drops per minute).

Treatment begins with the introduction of 200 mg (10 ml of a solution of 20 mg / ml) 1 time per day; then, with good tolerability, the dose is increased to 400 mg (20 ml of a solution of 20 mg / ml) 1-2 times a day. Duration of treatment is 10-15 days.

Jet injection of the drug is possible for acute heart rhythm disorders in a single dose of 200-400 mg (10-20 ml of a solution of 20 mg / ml).

For pharmacological protection of the kidneys subjected to ischemia, Riboxin is injected intravenously in a single dose of 1200 mg (60 ml of a solution of 20 mg / ml) 5-15 minutes before the compression of the renal artery, and then another 800 mg (40 ml of a solution of 20 mg / ml) immediately after the restoration of blood circulation.

When drip into the vein, the solution of the drug 20 mg / ml is diluted in a 5% solution of dextrose (glucose) or 0.9% solution of sodium chloride (up to 250 ml).

Side effects:

Allergic reactions: skin itching, skin hyperemia (drug should be discarded).

Rarely: increased concentration of uric acid in the blood, exacerbation of gout (with prolonged use).

Overdose:

Currently, there have been no cases of overdose.

Interaction:Clinically significant interaction with drugs of other groups was not revealed.

Effect on the ability to drive transp. cf. and fur:

Information about the effect of the drug Riboxin on the ability to drive vehicles and mechanisms there.

Form release / dosage:

Solution for intravenous administration, 20 mg / ml.

Packaging:

5 and 10 ml into neutral glass ampoules.

For 10 ampoules with instructions for use and a knife for opening ampoules or a scarifier placed in a box of cardboard.

5 or 10 ampoules are placed in a contoured cell pack of a polyvinyl chloride film or a polyethylene terephthalate tape and aluminum foil or paper with a polyethylene coating, or without a foil, or without paper.

For 1 or 2 contour cells with instructions for use and a knife for opening ampoules are placed in a pack of cardboard. When packaging ampoules with a break ring or break point, the ampoule opener or ampoule scarifier may not be inserted.

Storage conditions:

Store in a dark place at a temperature of 15 to 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after expiry date.

Terms of leave from pharmacies:On prescription

Registration number:P N001349 / 01

Date of registration:17.04.2007

The owner of the registration certificate:NOVOSIBHIMFARM, OJSC NOVOSIBHIMFARM, OJSC Russia

Manufacturer: & nbsp

NOVOSIBHIMFARM, OJSC Russia

Representation: & nbspNOVOSIBHIMFARM, OJSCNOVOSIBHIMFARM, OJSC

Information update date: & nbsp23.10.2015

Illustrated instructions

Instructions

Riboxin (Riboxin)