Active substanceInosineInosine
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  • Dosage form: & nbspcoated tablets
    Composition:

    1 tablet, coated, contains:

    active substance: inosine (riboxin) 0.2 g;

    Excipients: potato starch, methylcellulose, sugar, stearic acid;

    sheath: methylcellulose, tween-80, titanium dioxide, beeswax, dyes: tropeolin O, yellow water-soluble CF 6001, quinoline yellow E-104.

    Description:

    The tablets covered with a cover, from light yellow up to zelenovato yellow colors. Two layers are visible on the cross-section.

    Pharmacotherapeutic group:metabolic
    ATX: & nbsp

    C.01.E.B   Other drugs for the treatment of heart disease

    Pharmacodynamics:

    Riboxin belongs to the group of drugs that regulate metabolic processes. Purine derivative (nucleoside), the precursor of adenosine triphosphate (ATP).

    Has antihypoxic, metabolic and antiarrhythmic effect. Increases the energy balance of the myocardium, improves coronary circulation, prevents the consequences of intraoperative kidney ischemia. It takes a direct part in the exchange of glucose and promotes the activation of metabolism under conditions of hypoxia and in the absence of ATP.

    Activates the metabolism of pyruvic acid to ensure a normal process of tissue respiration, and also promotes the activation of xanthine dehydrogenase. Stimulates the synthesis of nucleotides, enhances the activity of certain enzymes of the Krebs cycle.Penetrating into cells, increases the energy level, has a positive effect on the metabolic processes in the myocardium - increases the strength of the contractions of the heart and promotes more complete relaxation of the myocardium in diastole, resulting in an increased shock volume.

    Reduces platelet aggregation, activates the regeneration of tissues (especially the myocardium and the mucous membrane of the gastrointestinal tract).

    Pharmacokinetics:

    Well absorbed in the digestive tract. It breaks down in the liver with the formation of glucuronic acid and its subsequent oxidation. In an insignificant amount excreted in the urine.

    Indications:

    Complex therapy of coronary heart disease, myocardial dystrophies, myocardial infarction, heart rhythm disorders caused by cardiac glycosides, hepatitis, liver cirrhosis, fatty liver disease caused by alcohol or drugs, urocoppororphyria.

    Contraindications:

    Hypersensitivity to the drug, gout, hyperuricemia, age of 18 years.

    Carefully:

    Renal failure.

    Dosing and Administration:

    Riboxin is prescribed inside before meals.

    The daily dose of the drug for oral administration is 0.6-2.4 g. In the first days of treatment, the daily dose is 0.6-0.8 g (0.2 g 3-4 times a day). If the drug is well tolerated, the dose is increased for 2-3 days to 1.2 g (0.4 g 3 times a day), if necessary - up to 2.4 g per day.

    The duration of the course is from 4 weeks to 1.5-3 months.

    With urocoppororphy, the daily dose is 0.8 g (0.2 g 4 times a day). The drug is taken daily for 1-3 months.

    Side effects:

    Allergic reactions in the form of urticaria, skin itching, skin hyperemia (the drug is canceled).

    Rarely in the treatment with riboxin, the concentration of uric acid in the blood increases, possibly an exacerbation of gout (with prolonged use).

    Form release / dosage:

    The tablets covered with a cover, 0,2 g.

    Packaging:

    For 10 tablets in a planar cell package (polyvinyl chloride film and aluminum foil); on 50 tablets in banks of type BDS from orange glass or in vials or polyethylene; 5 contour mesh packages or jar or bottle together with instructions for use are placed in a pack of cardboard.

    Storage conditions:

    In a dry place, protected from light and out of reach of children, at a temperature from 18 to 20 FROM.

    Shelf life:

    3 years.

    Do not use after the time specified on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:P N003133 / 01
    Date of registration:06.02.2009
    The owner of the registration certificate:Tyumen Chemical - Pharmaceutical Plant, OJSC Tyumen Chemical - Pharmaceutical Plant, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp23.10.2015
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