Active substanceInosineInosine
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  • Dosage form: & nbspfilm-coated tablets
    Composition:

    Each film-coated tablet contains:

    active substance: inosine (riboxin) (in terms of 100% substance) 200 mg;

    Excipients: potato starch 54.1 mg, methyl cellulose 3.2 mg, sucrose (sugar) 10.0 mg, stearic acid 2.7 mg;

    sheath: opedrai II yellow (alcohol polyvinyl, titanium dioxide, talc, macrogol 3350 (polyethylene glycol 3350), iron (III) oxide, lacquer aluminum based on quinoline yellow) 8.0 mg.

    Description:

    The tablets covered with a film cover, round, biconcave, slightly rough, from light yellow to yellow-orange color. On the cross-section, two layers are visible: the core is white or white with a slightly yellowish tinge; Sheath - from light yellow to yellow-orange color.

    Pharmacotherapeutic group:metabolic
    ATX: & nbsp

    C.01.E.B   Other drugs for the treatment of heart disease

    Pharmacodynamics:

    Inosine belongs to the group of drugs that regulate metabolic processes. The drug is a precursor of the synthesis of purine nucleotides: adenosine triphosphate and guanosine triphosphate.

    Has antihypoxic, metabolic and antiarrhythmic effect. Increases the energy balance of the myocardium, improves coronary circulation, prevents the consequences of intraoperative kidney ischemia.It takes a direct part in the exchange of glucose and promotes the activation of metabolism in conditions of hypoxia and in the absence of adenosine triphosphate.

    Activates the metabolism of pyruvic acid to ensure a normal process of tissue respiration, and also promotes the activation of xanthine dehydrogenase. Stimulates the synthesis of nucleotides, enhances the activity of certain enzymes of the Krebs cycle. Penetrating into cells, increases the energy level, has a positive effect on the metabolic processes in the myocardium, increases the strength of the heart contractions and promotes more complete relaxation of the myocardium in diastole, resulting in an increase in the shock volume of blood.

    Reduces platelet aggregation, activates the regeneration of tissues (especially the myocardium and mucous membrane of the gastrointestinal tract.

    Pharmacokinetics:

    It is well absorbed in the gastrointestinal tract. Metabolised in the liver with the formation of glucuronic acid and its subsequent oxidation. In a small amount is excreted by the kidneys.

    Indications:

    Assign adults in the complex therapy of coronary heart disease, after a heart attack, myocardial infarction, heart rhythm disorders due to the use of cardiac glycosides.

    Assign with hepatitis, cirrhosis, fatty liver, caused by alcohol or drugs and urocoppororphy.

    Contraindications:

    Hypersensitivity to the drug, gout, hyperuricemia.

    Fructose intolerance and glucose / galactose absorption disorder or sugar / isomaltase deficiency.

    Carefully:

    Renal insufficiency, diabetes mellitus.

    Pregnancy and lactation:

    The safety of the drug Riboxin during pregnancy and lactation is not established. Riboxin is contraindicated during pregnancy.

    For the duration of treatment with Riboxin, breastfeeding should be stopped.

    Dosing and Administration:

    Assign an adult inside before eating.

    The daily intake for oral administration is 0.6-2.4 g. In the first days of treatment, the daily dose is 0.6-0.8 g (200 mg 3-4 times a day). In case of good tolerance, the dose is increased (2-3 days) to 1.2 g (0.4 g 3 times a day), if necessary - up to 2.4 g per day.

    The duration of the course is from 4 weeks to 1.5-3 months.

    With urocoppororphy, the daily dose is 0.8 g (200 mg 4 times a day). The drug is taken daily for 1-3 months.

    Side effects:Allergic reactions are possible in the form of hives, itchy skin, skin hyperemia (drug withdrawal is required).
    Rarely with the treatment of the drug raises the concentration of uric acid in the blood and exacerbation of gout (with prolonged use).
    Overdose:

    Cases of overdose are unknown.

    Interaction:

    Immunosuppressants (azathioprine, antilympholine, ciclosporin, thymodepressin, etc.) with simultaneous use reduce the effectiveness of Riboxin.

    Special instructions:

    During the treatment with Riboxin, the concentration of uric acid in the blood and urine should be monitored.

    Information for patients with diabetes mellitus: 1 tablet of the drug corresponds to 0.00641 units of bread.

    Effect on the ability to drive transp. cf. and fur:

    Does not affect the ability to drive vehicles and manage mechanisms that require increased concentration.

    Form release / dosage:

    Tablets, film-coated, 200 mg.

    Packaging:

    For 10 or 25 tablets in a contour mesh package.

    5 contour cell packs of 10 tablets or 2 contourcell packs of 25 tablets together with instructions for use are placed in a cardboard pack.

    Storage conditions:

    In dry, dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LP-000240
    Date of registration:16.02.2011
    Date of cancellation:2016-02-16
    The owner of the registration certificate:TATHIMFARMPREPARATY, JSC TATHIMFARMPREPARATY, JSC Russia
    Manufacturer: & nbsp
    Representation: & nbspTATHIMFARM PREPARATIONS OJSC TATHIMFARM PREPARATIONS OJSC Russia
    Information update date: & nbsp22.10.2015
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