Active substanceInosineInosine
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  • Dosage form: & nbspsolution for intravenous administration
    Composition:1 ml of the preparation contains:

    active substance: inosine 20.0 mg;

    Excipients: sodium hydroxide 0.50 mg, water for injection up to 1 ml.

    Description:Transparent, colorless or slightly dyed yellow liquid.
    Pharmacotherapeutic group:Metabolic means
    ATX: & nbsp

    C.01.E.B   Other drugs for the treatment of heart disease

    Pharmacodynamics:

    Metabolic agent, a precursor of adenosine triphosphate (ATP); has antihypoxic, metabolic and antiarrhythmic effects. Increases the energy balance of the myocardium, improves coronary circulation, prevents the consequences of intraoperative kidney ischemia. It takes a direct part in the exchange of glucose and promotes the activation of metabolism in conditions of hypoxia and in the absence of ATP. Activates the metabolism of pyruvic acid to ensure a normal process of tissue respiration, and also promotes the activation of xanthine dehydrogenase. Stimulates the synthesis of nucleotides, enhances the activity of certain enzymes of the Krebs cycle. Penetrating into cells, increases the energy level, has a positive effect on the metabolic processes in the myocardium, increases the strength of the heart contractions and promotes more complete relaxation of the myocardium in diastole, resulting in an increase in the shock volume of blood.Reduces platelet aggregation, activates the regeneration of tissues (especially myocardium and gastrointestinal mucosa (GI tract)).

    Pharmacokinetics:

    Metabolised in the liver with the formation of glucuronic acid and its subsequent oxidation. In a small amount, it is excreted by the kidneys.

    Indications:

    Complex treatment of myocardial infarction, coronary heart disease, cardiac arrhythmias caused by the use of cardiac glycosides, against myocardial dystrophy after infectious diseases.

    Diseases of the liver (hepatitis, cirrhosis, fatty degeneration), urocoppororphyria.

    Operations on an isolated kidney (as a means of pharmacological protection when the circulation is turned off).

    Contraindications:

    Hypersensitivity to the drug, gout, hyperuricemia, age under 18 years (efficacy and safety not established).

    Carefully:

    Renal failure.

    Pregnancy and lactation:

    It is not recommended to use during pregnancy and lactation.

    Dosing and Administration:

    Intravenously injected slowly (40-60 drops per minute) drip or jet. Initially, 200 mg (10 ml of 2% solution) 1 time per day, in the following terms with good tolerability - up to 400 mg (20 ml 2% solution) 1-2 times a day. The course of treatment is 10-15 days.

    Jet injection is possible for acute heart rhythm disorders in a single dose of 200-400 mg (10-20 ml of a 2% solution).

    For pharmacological protection of the kidneys subjected to ischemia, inosine injected intravenously in a single dose of 1200 mg (60 mg 2% solution) for 5-15 minutes before clamping the renal artery, and then another 800 mg (40 ml of 2% solution) immediately after the restoration of blood circulation.

    When drip into the vein, 2% solution of the drug is diluted in 5% solution of glucose or isotonic sodium chloride solution (up to 250 ml).

    Side effects:

    When using Inosie-F®, individual intolerance is possible, manifested by itching, flushing of the skin.

    Rarely the concentration of uric acid in the blood increases.

    Perhaps an exacerbation of gout (prolonged use).

    Interaction:

    When combined with cardiac glycosides, the drug can prevent the occurrence of arrhythmias, enhance the positive inotropic effect.

    Special instructions:

    When itching and hyperemia of the skin, treatment with the drug should be discarded.

    During prolonged treatment it is desirable to control the level of uric acid in the blood and urine.

    Form release / dosage:

    Solution for intravenous administration of 20 mg / ml.

    Packaging:

    For 20 ml of the drug in neutral glass ampoules with a notch and a color mark.

    5 ampoules are placed in a contour mesh substrate.

    1 contour mesh substrate together with the instruction for use is placed in a cardboard box.

    Storage conditions:

    In the dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:3 years. Do not use after expiry date.
    Terms of leave from pharmacies:On prescription
    Registration number:LSR-007629/09
    Date of registration:29.09.2009
    Expiration Date:Unlimited
    The owner of the registration certificate:Europharm (UK) Co., Ltd.Europharm (UK) Co., Ltd. United Kingdom
    Manufacturer: & nbsp
    Representation: & nbspEPIDBIOMED-IMPEX LLC EPIDBIOMED-IMPEX LLC Russia
    Information update date: & nbsp31.10.2017
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