Active substanceInosineInosine
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  • Dosage form: & nbspfilm-coated tablets
    Composition:

    Each tablet contains:

    active substance: inosine 200 mg;

    auxiliary substances (core): cellulose microcrystalline 40.0 mg, sucrose 40.0 mg, starch potato 17.0 mg, povidone (polyvinylpyrrolidone) 10.0 mg, croscarmellose sodium 6.0 mg, magnesium stearate 3.0 mg, purified water 4,0 mg;

    Excipients (shell): hypromellose 5.5 mg, polysorbate-80 1.5 mg, titanium dioxide 3.0 mg.

    Description:

    Tablets without risks of biconvex form, covered with a film shell of white or almost white color. The presence of a slight surface roughness is allowed.

    Pharmacotherapeutic group:metabolic
    ATX: & nbsp

    C.01.E.B   Other drugs for the treatment of heart disease

    Pharmacodynamics:

    Metabolic agent, the precursor of ATP; has antihypoxic, metabolic and antiarrhythmic effects. Increases the energy balance of the myocardium, improves coronary circulation, prevents the consequences of intraoperative kidney ischemia. It takes a direct part in the exchange of glucose and promotes the activation of metabolism in conditions of hypoxia and in the absence of ATP. Activates the metabolism of pyruvic acid to ensure a normal process of tissue respiration, and also promotes the activation of xanthine dehydrogenase. Stimulates the synthesis of nucleotides, enhances the activity of certain enzymes of the Krebs cycle.Penetrating into cells, increases the energy level, has a positive effect on the metabolic processes in the myocardium - increases the strength of the contractions of the heart and promotes more complete relaxation of the myocardium in diastole, resulting in an increased shock volume. Reduces platelet aggregation, activates the regeneration of tissues (especially myocardium and gastrointestinal mucosa (GI tract)).

    Pharmacokinetics:

    It is well absorbed in the digestive tract. Metabolised in the liver with the formation of glucuronic acid and its subsequent oxidation. In a small amount, it is excreted by the kidneys.

    Indications:

    Assign adults in the complex therapy of coronary heart disease, myocardial dystrophy, after myocardial infarction, heart rhythm disorders due to the use of cardiac glycosides.

    Assign with hepatitis, cirrhosis, fatty liver, caused by alcohol or drugs and urocoppororphy.

    Contraindications:

    Hypersensitivity to the drug, gout, hyperuricemia.

    Pregnancy, lactation.

    Age to 18 years.

    Carefully:

    Renal failure.

    Dosing and Administration:

    Assign inside before eating.

    The daily intake dose is 0.6-2.4 g.In the first days of treatment, the daily dose is 0.6-0.8 g (0.2 g 3-4 times a day). In case of good tolerance, the dose is increased (2-3 days) by 1.2 g (0.4 g 3 times a day), if necessary - up to 2.4 g per day.

    The duration of the course is from 4 weeks to 1.5-3 months.

    With urocoppororphy, the daily dose is 0.8 g (0.2 g 4 times a day). The drug is taken daily for 1-3 months.

    Side effects:

    Allergic reactions are possible in the form of hives, itchy skin, skin hyperemia (drug withdrawal is required).

    Rarely with the treatment of the drug raises the concentration of uric acid in the blood and exacerbation of gout (with prolonged use).

    Form release / dosage:

    Tablets, film-coated, 200 mg

    Packaging:

    For 10, 25 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil printed lacquered.

    By 10, 20, 30, 40, 50 or 100 tablets into a polymer container for medicines.

    One container or 1, 2, 3, 4, 5 or 10 contour mesh packages together with the instruction for use are placed in a pack of cardboard.

    Storage conditions:

    Store in a dry, dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use after expiry date.

    Terms of leave from pharmacies:On prescription
    Registration number:LSR-000605/09
    Date of registration:30.01.2009
    The owner of the registration certificate:OZONE, LLC OZONE, LLC Russia
    Manufacturer: & nbsp
    Representation: & nbspOZONE LLC OZONE LLC Russia
    Information update date: & nbsp23.10.2015
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