Active substanceInosineInosine
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  • Dosage form: & nbspsolution for intravenous administration
    Composition:

    1 ml of the solution contains:

    active substance: riboxin (inosine) 20 mg;

    Excipients: hexamethylenetetramine (methenamine), sodium hydroxide solution 1 M (sodium hydroxide), water for injection.

    Description:

    Transparent colorless or slightly colored liquid.

    Pharmacotherapeutic group:metabolic
    ATX: & nbsp

    C.01.E.B   Other drugs for the treatment of heart disease

    Pharmacodynamics:

    Riboxin is a derivative (nucleoside) of purine, a precursor of adenosine triphosphate (ATP). Refers to a group of drugs that stimulate metabolic processes. Has antihypoxic and antiarrhythmic effect. Increases the energy balance of the myocardium, improves coronary circulation, prevents the consequences of intraoperative kidney ischemia. It takes a direct part in the exchange of glucose and promotes the activation of metabolism under conditions of hypoxia and in the absence of ATP.

    Activates the metabolism of pyruvic acid necessary to ensure the normal process of tissue respiration, and also promotes the activation of xanthine dehydrogenase. Stimulates the synthesis of nucleotides, enhances the activity of certain enzymes of the Krebs cycle. Penetrating into cells, has a positive effect on metabolic processes in the myocardium - increases the strength of the heart contractions and promotes more complete relaxation of the myocardium in diastole,as a result of which the shock volume increases. The mechanism of antiarrhythmic action is not fully understood.

    Reduces platelet aggregation, activates the regeneration of tissues (especially the myocardium and the mucous membrane of the gastrointestinal tract).

    Pharmacokinetics:

    Metabolised in the liver with the formation of glucuronic acid and its subsequent oxidation.

    In an insignificant amount excreted in the urine.

    Indications:

    Complex treatment of myocardial infarction, coronary heart disease, cardiac arrhythmias caused by the use of cardiac glycosides, against myocardial dystrophy after infectious diseases.

    Diseases of the liver (hepatitis, cirrhosis, fatty degeneration), urocoppororphyria.

    Operations on an isolated kidney (as a means of pharmacological protection when the circulation is turned off).

    Contraindications:

    Hypersensitivity to the drug, gout, hyperuricemia, pregnancy, lactation, age under 18 years (efficacy and safety not established).

    Carefully:With renal failure.
    Dosing and Administration:

    The drug is used intravenously struino slowly or drip (40-60 drops in 1 minute).Treatment begins with the introduction of 200 mg (10 ml of 2% solution) once a day, then, with good tolerability, the dose is increased to 400 mg (20 ml of 2% solution) 1-2 times a day. Duration of treatment is 10-15 days.

    Jet injection of the drug is possible for acute heart rhythm disorders in a single dose of 200-400 mg (10-20 ml of a 2% solution).

    For pharmacological renal protection subjected to ischemia Riboxinum administered intravenously in a single dose of 1200 mg (60 ml of a 2% solution) for 5-15 minutes prior to clamping of the renal artery, then another 800 mg (40 ml of a 2% solution) immediately after restoration of blood circulation .

    When drip into the vein 2% solution of the drug is diluted in 5% dextrose (glucose) or isotonic sodium chloride solution (250 mL).

    Side effects:

    Allergic reactions: skin itching, skin hyperemia (drug should be discarded).

    Rarely: increased concentration of uric acid in the blood, exacerbation of gout (with prolonged use).

    Form release / dosage:Solution for intravenous administration, 20 mg / ml.
    Packaging:

    For 10 ml in ampoules.

    Of 10 vials together with instructions for use and knife or lancet ampoule ampoule in a box or pack of cardboard.

    Storage conditions:

    In the dark place at a temperature of 15 to 30 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use after expiry date.

    Terms of leave from pharmacies:On prescription
    Registration number:P N000301 / 01
    Date of registration:01.04.2008
    The owner of the registration certificate:VEROPHARM SA VEROPHARM SA Russia
    Manufacturer: & nbsp
    Representation: & nbspVEROPHARM, AO VEROPHARM, AO Russia
    Information update date: & nbsp23.10.2015
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