Active substanceInosineInosine
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  • Dosage form: & nbspfilm-coated tablets
    Composition:

    For one tablet:

    active substance: Riboxin (inosine) in terms of 100% substance 200 mg;

    auxiliary substances (core): potato starch 43.6976 mg, sucrose (sugar) 9.0187 mg, povidone (low molecular weight polyvinylpyrrolidone) 14.5523 mg, stearic acid 0.4123 mg, magnesium stearate 2.3191 mg;

    auxiliary substances (shell): AdvantiaPrime 344950RA09 (hypromellose 3.3 mg, titanium dioxide 1,11975 mg, glyceride caprylcaprate (caprylic / capric triglyceride) 0.45 mg, iron dye oxide yellow 0.035 mg, dye quinoline yellow 0,095 mg, iron oxide dye red 0.00025 mg).

    Description:

    Round tablets, biconvex, covered with a film coat from light yellow to yellow-orange color. On the cross-section, two layers are visible: the first from light yellow to yellow-orange, the second white. A slight unevenness of the coating is allowed.

    Pharmacotherapeutic group:metabolic
    ATX: & nbsp

    C.01.E.B   Other drugs for the treatment of heart disease

    Pharmacodynamics:

    Inosine belongs to the group of drugs that regulate metabolic processes. Purine derivative (nucleoside), the precursor of adenosine triphosphate (ATP).

    Has antihypoxic, metabolic and antiarrhythmic effect. Increases the energy balance of the myocardium, improves coronary circulation, prevents the consequences of intraoperative kidney ischemia. It takes a direct part in the exchange of glucose and promotes the activation of metabolism in conditions of hypoxia and in the absence of ATP.Activates the metabolism of pyruvic acid to ensure a normal process of tissue respiration, and also promotes the activation of xanthine dehydrogenase. Stimulates the synthesis of nucleotides, enhances the activity of certain enzymes of the Krebs cycle. Penetrating into cells, increases the energy level, has a positive effect on the metabolic processes in the myocardium, increases the strength of the heart contractions and promotes more complete relaxation of the myocardium in diastole, resulting in an increase in the shock volume of blood.

    Reduces platelet aggregation, activates the regeneration of tissues (especially the myocardium and mucous membrane of the gastrointestinal tract).

    Pharmacokinetics:

    It is well absorbed in the gastrointestinal tract. Metabolised in the liver with the formation of glucuronic acid and its subsequent oxidation. In a small amount is excreted by the kidneys.

    Indications:

    Riboxin is prescribed to adults as part of complex therapy of myocardial infarction, ischemic heart disease, myocardial dystrophy, cardiac arrhythmias caused by glycosidic intoxication.

    Assign with hepatitis, liver cirrhosis, fatty liver disease caused by alcoholism or the use of hepatotoxic drugs, urocoppororphyria.

    Contraindications:

    Hypersensitivity to the drug, gout, hyperuricemia.

    Carefully:

    Renal failure.

    Dosing and Administration:

    Riboxin is prescribed inside before meals.

    The daily dose of the drug for oral administration is 0.6-2.4 g. In the first days of treatment, the daily dose is 0.6-0.8 g (200 mg 3-4 times a day). If the drug is well tolerated, the daily dose is increased for 2-3 days to 1.2 g (0.4 g 3 times a day), if necessary - up to 2.4 g per day.

    The duration of the course is from 4 weeks to 1.5-3 months.

    With urocoppororphy, the daily dose is 0.8 g (200 mg 4 times a day). The course of treatment - 1-3 months.

    Side effects:

    Allergic reactions are possible in the form of hives, itchy skin, skin hyperemia (drug withdrawal is required).

    Rarely with the treatment of the drug raises the concentration of uric acid in the blood (hyperuricemia).

    Perhaps an exacerbation of gout (with prolonged use).

    Form release / dosage:

    Tablets, film-coated, 200 mg.

    Packaging:

    10 tablets are placed in a contour mesh package made of a polyvinylchloride film and foil.

    5 contour mesh packages together with the instruction for use are placed in a pack of cardboard.

    Storage conditions:

    Store in a dry, dark place at a temperature of no higher than 30 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:P N001004 / 01
    Date of registration:04.06.2009
    The owner of the registration certificate:MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC Russia
    Manufacturer: & nbsp
    Representation: & nbspMOSHIMFARM PREPARATES them. NA Semashko OJSC MOSHIMFARM PREPARATES them. NA Semashko OJSC Russia
    Information update date: & nbsp22.10.2015
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