It is established individually taking into account the severity of the course and localization of the infection, the sensitivity of the pathogen.
The drug can be administered intramuscularly, intravenously (struino or drip).
Average daily dose for adults is 1 g; the frequency of administration is 2 times a day. The maximum daily dose is 6 g; the frequency of administration can be increased up to 3-4 times a day.
For the prevention of postoperative infectious complications prescribe 1 g of cefazolin 30 minutes prior to surgery; 0.5-1 g during the operation and 0.5-1 g every 6-8 hours during the day after the operation.
Average daily dose for children is 20-50 mg / kg body weight; In severe infections, the dose can be increased to 100 mg / kg per day.
The average duration of treatment is 7-10 days.
In patients with impaired renal function The dosage regimen of cefazolin is set taking into account the values of creatinine clearance. With SC greater than 55 ml / min (or serum creatinine less than 1.5 mg%), the dosing regimen, as a rule, does not require correction. When QA 35-54 ml / min (serum creatinine less than or 1,6-3% mg) single dose may remain unchanged, however, should increase the interval between administrations to 8 hours.
With CC 11-34 ml / min (or serum creatinine 3.1-4.5 mg%) single dose should be reduced by 2 times; intervals between administrations are 12 hours. With SC less than 10 ml / min (or serum creatinine more than 4.6 mg%), one-half of the usual dose is prescribed every 18-24 hours. All recommendations for prescribing low doses are applied after an initial loading dose corresponding to the severity of the infection is established.
For intramuscular injection, the drug is dissolved in 4-5 ml of water for injection, isotonic sodium chloride solution or 0.25-0.5% solution of novocaine.
For intravenous drip, the drug is dissolved in 100 250 ml of isotonic sodium chloride solution or 5% glucose solution; the injection is carried out for 20-30 minutes (the rate of administration is 60-80 drops per minute).
For intravenous fluid administration, a single dose of the drug is diluted in 10 ml of isotonic sodium chloride solution and injected slowly for 3-5 minutes.