Enter intramuscularly or intravenously (struino or drip).
Adults
Recommended doses for adults, depending on the nature of the infection, are listed in Table 1.
Table 1
| Nature of infection | Single dose | Frequency of administration |
| Infections of medium gravity and severe | 0.5-1 g | Every 6-8 hours |
| An easy form of infection caused by sensitive Gram-positive cocci | 0.25-0.5 g | Every 8 hours |
| Acute uncomplicated urinary tract infection | 1 g | Every 12 hours |
| Pneumococcal pneumonia | 0.5 g | Every 12 hours |
| Severe, life-threatening infections (eg, sepsis, endocarditis) | 1-1.5 g | Every 6 hours |
The maximum daily dose is -6 g.
The average duration of treatment is 7-10 days.
Prevention of surgical infections
Enter 1 g for 0.5-1 h before surgery. At long operations - 0,5-1 g during the operation. If necessary, inject 0.5-1 g every 6-8 hours during the first day after the operation.
Adults with impaired renal function
A change in the dosing regimen is required in accordance with the creatinine clearance value (Table 2) after the initial dose, which should correspond to the nature and severity of the infection (see Table 1).
table 2
| Creatinine clearance, ml / min | Concentration of creatinine in plasma, mg% | % daily dose | Interval between administrations, hour |
| 55 and more | 1.5 and less | 100 | 6-8 |
| 35-54 | 1,6-3,0 | 100 | 8 |
| 11-34 | 3,1-4,5 | 50 | 12 |
| 10 or less | 4.6 and more | 50 | 18-24 |
Children
The average daily dose for children (over the month) is 25-50 mg / kg; In severe infection, the dose can be increased to 100 mg / kg / day. Multiplicity of administration - 3-4 times a day.
Children with impaired renal function
Correction of the dosing regimen is performed depending on the values of creatinine clearance (Table 3).All recommended doses are administered after the initial dose, which should match the nature and severity of the infection (see Table 1).
Table 3
| Creatinine clearance, ml / min | % daily dose | Interval between administrations, hour |
| 70-40 | 60 | 12 |
| 39-20 | 25 | 12 |
| 19-5 | 10 | 24 |
Preparation of solution and method of administration
Intramuscularly
1 g of the drug is dissolved in 2.5 ml of water for injection or 0.9% solution of sodium chloride and injected deep into the muscle (for example, in the upper outer quadrant of the gluteus muscle). The approximate final volume and approximate final concentration of the resulting solution are indicated in Table 4.
Table 4
| Dosage | Volume of solvent | Approximate final volume | Approximate final concentration |
| 1 g | 2.5 ml | 3.0 ml | 330 mg / ml |
Intravenously
Streaming: 1 g is dissolved in 10 ml of water for injection or 0.9% solution of sodium chloride; injected slowly for 3-5 minutes.
Drip: 1 g is dissolved in 100-250 ml of 5% glucose solution (dextrose) or 0.9% sodium chloride solution; injected for 20-30 minutes at a rate of 60-80 drops per minute.
During the dilution the vial must be vigorously shaken until the powder is completely dissolved.
The color change of the solution to yellowish does not mean a loss of activity of the preparation.