Intramuscularly, intravenously (struyno and drip).Dosing regimen and duration of treatment are set individually, taking into account the indications, severity of the course, localization of infection and sensitivity of the pathogen. Average daily dose for adults - 1-4 g; the frequency of administration is 3-4 times a day. The maximum daily dose is 6 g. The average duration of treatment is 7-10 days.
For infections of moderate severity caused by sensitive Gram-positive microorganisms, a single dose for adults is 0.25-0.5 g every 8 hours.
With pneumococcal pneumonia - 0.5 g every 12 hours.
In acute uncomplicated diseases of the urinary tract - 1 g every 12 hours.
For the prevention of postoperative infection - intravenously 1 g for 30 - 60 minutes before surgery, 0.5-1 g - during surgery and 0.5-1 g - every 8 hours during the first day after surgery.
Patients with impaired renal function require a change in the dosage regimen in accordance with the values of creatinine clearance:
- with a creatinine clearance of 55 ml / min or more, or with a creatinine concentration in plasma of 1.5 mg% or less, a full dose can be administered;
- with a creatinine clearance of 54-35 ml / min or with a plasma creatinine concentration of 3-1.6 mg% - a full dose can be administered, but the intervals between injections can be increased to 8 hours;
with clearance of creatinine 34-11 ml / min or at a concentration of creatinine in plasma of 4.5-3.1 mg% 1/2 doses at intervals of 12 h;
- with a creatinine clearance of 10 ml / min or less, or with a plasma creatinine concentration of 4.6 mg% or more - 1 /2 average dose every 18-24 hours.
All recommended doses are administered after the initial dose corresponding to the severity of the flow.
Average daily dose for children 1 month and older - 25-50 mg / kg; at a heavy current of an infection the dose can be increased up to 100 mg / kg / sut. Multiplicity of administration - 3-4 times a day.
In children with impaired renal function, the dosage regimen is adjusted depending on the values of creatinine clearance:
- with creatinine clearance of 70-40 ml / min - 60% of the average daily dose and injected every 12 hours;
- at the clearance of creatinine 40-20 ml / min - 25% of the average daily dose with an interval of 12 hours;
- - with creatinine clearance of 5-20 ml / min - 10% of the average daily dose every 24 hours.
All recommended doses are administered after the initial "shock" dose corresponding to the severity of the flow.
Preparation of solutions:
For intramuscular injection: 0.5 g of the drug is dissolved in 2 ml of water for injection, 1 g in 4 ml of water for injection.
For intravenous drip the preparation is dissolved in 50-100 ml of 0.9% sodium chloride solution, 5-10% dextrose solution, Ringer's solution, 5% sodium bicarbonate solution.
For intravenous bolus introduction of a single dose of the drug is diluted in 10 ml of water for injection and injected slowly for 3-5 minutes.
During the dilution, the vials are vigorously shaken until completely dissolved.