Cefazolin Sandoz is intended for intravenous (including in the form of infusion) and intramuscular injection.
Doses depend on the sensitivity of the pathogens, which caused infection, and severity course of the disease.
Adults
Standard doses used to treat adults:
|
| Dose | Frequency of introductions | Daily dose |
| Infections of mild degree | 500 mg | every 8 hours | 1.5 g |
| gravity | 1 g | every 12 hours | 2 grams |
| Uncomplicated infections urinary tract | 1 g | every 12 hours | 2 grams |
| Infections of moderate severity and severe infections | 1 g | every 6-8 hours | 3-4 grams |
| Life-threatening infections | From 1 g to 1.5 g | every 6 hours | 4 - 6 g |
In rare cases, doses up to 12 g were used.
Recommendations for dosing regimens adult patients with renal insufficiency:
| Creatinine clearance (ml / min / 1.73 m2) | Serum creatinine (mg / 100 mL) | Daily dose | Interval between administrations |
| >55 | <1,5 | Usual Dose | Without changes |
| 35-54 | 1,6-3,0 | Usual Dose | With an interval of 12 hours |
| 11-34 | 3,1-4,5 | 50% of the usual dose | With an interval of 12 hours |
| < 10 | >4,6 | 25% of the usual dose | With an interval of 24 hours |
Prevention of postoperative infection.
For 30 minutes - 1 hour before the operation, intravenous or intramuscular injection of the initial dose of 1 to 2 g.
In long-term operations (2 hours and longer), another 500 mg-1 g during the operation is administered intravenously or intramuscularly. The dose and time of administration depend on the type and duration of the operation.
After the operation, 500 mg - 1 g intravenously or intramuscularly with an interval of 6-8 hours is administered within 24 hours.
If potential infections pose a great danger to the patient (eg, after heart surgery or a serious orthopedic operation, such as complete joint replacement), it is recommended to continue the postoperative injection of the drug for 24-48 hours.
For elderly patients correction of doses is not required.
Children aged 1 month and older.
The daily dose for the treatment of infections of mild and moderate severity is 25 - 50 mg / kg body weight, is administered in 3-4 doses.
In cases of severe infection, the daily dose may be increased to the maximum recommended dose of 100 mg / kg body weight.
Recommendations on the dosage regimen in the treatment of children with renal insufficiency
| Creatinine clearance (ml / min / 1.73 m2) | The dose of cefazolin (mg / kg) | Dosing interval (h) |
| >50 | 7 (up to 500 mg per administration) | 6 to 8 |
| 25-50 | 7 | 12 |
| 10-25 | 7 | 24 to 36 |
| < 10 | 7 | 48 to 72 |
At the beginning of treatment for children who undergo hemodialysis, the drug is administered at a dose of 7 mg / kg body weight. Since during the dialysis, serum cefazolin level is reduced by 35-65%, a dose of 3-4 mg / kg body weight is introduced between the dialysis procedures (the interval between dialysis procedures is 72 hours).
Duration of treatment depends on the course of the disease. In accordance with the principles of antibiotic therapy, treatment with cefazolin is recommended to continue for at least 2-3 days after the disappearance of the febrile condition and / or obtaining confirmation of the eradication of the pathogen.
Preparation of solutions for intramuscular injection.
For intramuscular administration of Cefazolin Sandoz 1 g of the drug is dissolved in 4 ml, 0.5 g - in 2 ml of a 0.5% solution of lidocaine or water for injection.
The maximum dose for intramuscular injection is 1 g, is injected deep into the muscle.
When treating children under the age of 1 year should not be dissolved cefazolin in solutions of lidocaine.
Preparation of solutions for intravenous administration.
Solutions cefazolina with lidocaine should not be used for intravenous administration.
For intravenous administration, Cefazolin Sandoz is dissolved in water for injection or a 0.9% solution of sodium chloride (at least 4 ml of solution is required to dissolve each gram of the powder). By slow intravenous injection (3-5 min), up to 1 g of cefazolin can be administered.
To administer higher daily doses (4 to 6 g in 2 to 3 doses), intravenous infusion is used.
To prepare a solution for intravenous infusion the drug is dissolved in 50-100 ml of a 0.9% solution of sodium chloride or 5% solution of dextrose, injected for 20-30 minutes.
During the dilution, vials should be vigorously shaken until the drug is completely dissolved. Only transparent and colorless solutions are used.