Cefazolin is intended only for parenteral administration - intramuscularly and intravenously (streamwise or drip). Doses are set individually, taking into account the severity of the course and localization of the infection, the sensitivity of the pathogen.
Preparation of solutions and application:
For the / m introduction, 0.5 g of the drug is dissolved in 2 ml of water for injection, 1 g in 4 ml of water for injection. For intravenous administration, a single dose of the drug is diluted in 10 ml of water for
injections, then injected slowly, within 3-5 minutes. For IV injection drip 50-100 ml of 5-10% dextrose solution, 0.9% sodium chloride solution, Ringer's solution, 5% hydrogen carbonate solution; infusion is carried out for 20-30 minutes (rate of administration - 60-80 drops per minute). During the dilution, vials should be vigorously shaken until completely dissolved.
The average daily intake for adults is 1-4 g; the frequency of administration is 3-4 times a day. The maximum daily dose -
6 g. The average duration of treatment is 7-10 days.
Instructions on the dosing regimen for adults:
Cefazolin is intended only for parenteral administration - intramuscularly and intravenously
(streamwise or drip).Doses are set individually, taking into account the severity of the course and localization of the infection, the sensitivity of the pathogen.
Preparation of solutions and application:
For the / m introduction, 0.5 g of the drug is dissolved in 2 ml of water for injection, 1 g in 4 ml of water for injection. For intravenous administration, a single dose of the drug is diluted in 10 ml of water for
injections, then injected slowly, within 3-5 minutes. For IV injection drip 50-100 ml of 5-10% dextrose solution, 0.9% sodium chloride solution, Ringer's solution, 5% hydrogen carbonate solution; infusion is carried out for 20-30 minutes (rate of administration - 60-80 drops per minute). During the dilution, vials should be vigorously shaken until completely dissolved.
The average daily intake for adults is 1-4 g; the frequency of administration is 3-4 times a day. The maximum daily dose is 6 g. The average duration of treatment is 7-10 days.
Instructions on the dosing regimen for adults:
| View infection | Single dose | Frequency of administration |
| Infections of the lung course caused by sensitive Gram-positive cocci | 0.5-1 g | After 8 hours |
| Pneumococcal pneumonia | 0.5 g | In 12 hours |
| Acute uncomplicated urinary tract infections | 1 g | In 12 hours |
| Moderately heavy or heavy | 0.5-1 g | After 6-8 hours |
| Severe, life-threatening infections: endocarditis, septicemia | 1-1.5 g | In 6 hours |
Use in children with normal renal function:
Children aged 1 month and older cefazolin appoint a dose of 25-50 mg / kg body weight per day ,.
Multiplicity of administration - 3-4 times a day. In severe infection, the daily dose of cefazoln can be increased to 100 mg / kg of body weight. Multiplicity of administration - 3-4 times a day.
Application in adult patients with impaired function of night
In patients with impaired renal function, a change in the dosage regimen is required in accordance with the value of creatinine clearance (CC): with a CC of 55 ml / min or more, or with a creatinine concentration in the blood plasma of 1.5 mg% or less, a full daily dose can be administered; with SC 54-35 ml / min or at a concentration of creatinine in blood plasma of 3-1.6 mg%, a full daily dose can be administered, but the intervals between injections should be increased to 8 hours: with SC 34-11 ml / min or more the concentration of creatinine in blood plasma is 4.5-3.1 mg% administered half the usual dose every 18-24 hours. All recommended doses are administered after the initial, appropriate indication and severity of the infection.
Application in children with impaired renal function
Children who have a creatinine clearance of 70 to 40 ml / min / 1.73 m2, 60% of the average daily dose of cefazolinum is administered after 12 hours. When the creatinine clearance is from 40 to 20 ml / min / 1.73 m2 25% of the average daily dose of cefazolin is administered after 12 hours. With a clearance of creatinine between 20 and 5 ml / min / 1.73 m2 10% of the average daily dose of cefazolin is administered after 24 hours. All recommended doses are administered after the initial, corresponding severity of the infection.
Perioperative prophylaxis:
To prevent infections during surgical interventions, the dosage of cefazolin depends on the type and duration of the operation.
- 1 g is administered intravenously or intramuscularly for 30 minutes - 1 hour before the start of the surgery (the dose is sufficient for minor surgical interventions of short duration);
- for prolonged surgical operations (more than 2 hours), in addition, from 0.5 to 1 g intravenously or intramuscularly during the operation (you can enter the drug and during
surgical operation, depending on its duration - through certain intervals of time);
- during the postoperative period after the initial dose, doses from 0.5 g to 1 g intravenously or intramuscularly with an interval of 6-8 hours for 24 hours;
- if a potential infection can pose a threat to the patient (for example, after heart surgery or after extensive orthopedic operations such as arthroplasty), it is recommended to continue the post-operative administration of cefazolin for a period of 3 to 5 days.
It is important to comply with the above dates so that sufficient concentrations of antibiotic are already present in the serum and tissues of the patient during the surgical incision.